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Date: 27.11.2025
The new two-photon microscope for intravital fluorescence imaging and photostimulation, funded by the German Research Foundation (DFG) and the Ministry of Science, Research and the Arts of Baden-Württemberg, is now fully installed and operational at the Mannheim Medical Faculty. Managed by Prof. Simon Wiegert and his team at the Department of Neurophysiology, this advanced instrument enables the all-optical manipulation and monitoring of neuronal circuits with cellular resolution, marking a significant milestone for the research community.
Located at the Live Cell Imaging Mannheim (LIMa) core facility, the system is now available for researchers to use. The two-photon microscope allows for long-term, high-resolution imaging of neuronal dynamics in vivo, alongside holographic optogenetic manipulation. This enables groundbreaking studies in neuroinflammation, brain tumor immunology, nociception, and other key areas of neuroscience. Researchers are encouraged to explore the potential of this powerful tool in unraveling the complexities of the central nervous system and beyond.
Contact:
Prof. Dr. Simon Wiegert
Department of Neurophysiology
Medical Faculty Mannheim of Heidelberg University
Tridomus, Haus C
Ludolf-Krehl-Straße 13-17
68167 Mannheim
Phone: +49 (0)621 383-71400
E-Mail: neurophys@medma.uni-heidelberg.de
Previous news 25.03.2024:
Combination of Multiphoton Microscopy and Optogenetics – DFG Approves Major Instrumentation Research Proposal
