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2024
Stüdemann T, Schwarzová B, Schneidewind T, Geertz B, von Bibra C, Nehring M, Rössinger J, Wiegert JS, Eschenhagen T, Weinberger F. Impulse initiation in engrafted pluripotent stem cell-derived cardiomyocytes can stimulate the recipient heart. Stem Cell Reports. 2024 Jul 10:S2213-6711(24)00192-9. DOI: 10.1016/j.stemcr.2024.06.012
Heesen SH , Köhr G. GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids. Front Cell Neurosci. 2024; 18: 1389335. DOI: 10.3389/fncel.2024.1389335
Faust D, Wenz C, Holm S, Harms G, Greffrath W, Dietrich C. Cell-cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium. Arch Toxicol. 2024 May 30. DOI: 10.1007/s00204-024-03792-5
Wietek J, Nozownik A, Pulin M, Saraf-Sinik I, Matosevich N, Gowrishankar R, Gat A, Malan D, Brown BJ, Dine J, Imambocus BN, Levy R, Sauter K, Litvin A, Regev N, Subramaniam S, Abrera K, Summarli D, Goren EM, Mizrachi G, Bitton E, Benjamin A, Copits BA, Sasse P, Rost BR, Schmitz D, Bruchas MR, Soba P, Oren-Suissa M, Nir Y, Wiegert JS, Yizhar O. A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits. Nat Methods 2024 May 29. DOI: 10.1038/s41592-024-02285-8
Martel RD, Papafragou G, Weigand S, Rolke R, Prawitt D, Birklein F, Treede RD, Magerl W. Interindividual variability in cold-pressor pain sensitivity is not explained by peripheral vascular responding and generalizes to a C-nociceptor–specific pain phenotype. Pain 2024 Mar 1;165(3):e1-e14. DOI: 10.1097/j.pain.0000000000003049
2023
Schwarzová B, Stüdemann T, Sönmez M, Rössinger J, Pan B, Eschenhagen T, Stenzig J, Wiegert JS, Christ T, Weinberger F. Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES. Pflugers Arch. Dec;475(12):1463-1477. DOI: 10.1007/s00424-023-02869-x.
Danyukova T, Alimy AR, Velho RV, Yorgan TA, Di Lorenzo G, von Kroge S, Tidow H, Wiegert JS, Hermans-Borgmeyer I, Schinke T, Rolvien T, Pohl S. Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2 variant display a compromised subchondral osteocyte lacunocanalicular network associated with abnormal articular cartilage. Bone. 2023 Oct 3:116927. doi: 10.1016/j.bone.2023.116927.
D. Wang, R-D. Treede, G. Köhr, Electrophysiological evidence that TRPM3 is a candidate in latent spinal sensitization of chronic low back pain. Neurosci Lett 2023. doi: 10.1016/j.neulet.2023.137509
Michael M, Wolf BJ, Klinge-Strahl A, Jeschke M, Moser T, Dieter A. Devising a framework of optogenetic coding in the auditory pathway: Insights from auditory midbrain recordings. Brain Stimul. 2023 Sep 29:S1935-861X(23)01920-4. doi: 10.1016/j.brs.2023.09.018.
Schmidt H, Blechschmidt V. Nociplastic pain in research and practice: Overview of biopsychosocial principles, possibilities and difficulties. Schmerz. 2023 Aug;37(4):242-249. doi: 10.1007/s00482-023-00734-5.
Nicolas C, Ju A, Wu Y, Eldirdiri H, Delcasso S, Couderc Y, Fornari C, Mitra A, Supiot L, Vérité A, Masson M, Rodriguez-Rozada S, Jacky D, Wiegert JS, Beyeler A. Linking emotional valence and anxiety in a mouse insula-amygdala circuit. Nat Commun. 2023 Aug 21;14(1):5073. doi: 10.1038/s41467-023-40517-1.
Kagiampaki Z, Rohner V, Kiss C, Curreli S, Dieter A, Wilhelm M, Harada M, Duss SN, Dernic J, Bhat MA, Zhou X, Ravotto L, Ziebarth T, Wasielewski LM, Sönmez L, Benke D, Weber B, Bohacek J, Reiner A, Wiegert JS, Fellin T, Patriarchi T. Sensitive multicolor indicators for monitoring norepinephrine in vivo. Nat Methods. 2023 Jul 20. doi: 10.1038/s41592-023-01959-z.
Wietek J, Nozownik A, Pulin M, Saraf-Sinik I, Matosevich N, Malan D, Brown BJ, Dine J, Levy R, Litvin A, Regev N, Subramaniam S, Bitton E, Benjamin A, Copits BA, Sasse P, Rost BR, Schmitz D, Soba P, Nir Y, Wiegert JS, Yizhar O. A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits. bioRxiv. 2023 Jul 2:2023.07.01.547328. doi: 10.1101/2023.07.01.547328.
Wiegert JS, Spehr M, Hanganu-Opatz IL. Systems neuroscience: A box full of tools to illuminate the black box of the brain. PLoS Biol. 2023 Jul 27;21(7): e3002221. doi: 10.1371/journal.pbio.3002221.
Heumüller-Klug S, Maurer K, Tapia-Laliena MÁ, Sticht C, Christmann A, Mörz H, Khasanov R, Wink E, Schulte S, Greffrath W, Treede RD, Wessel LM, Schäfer KH. Impact of cryopreservation on viability, gene expression and function of enteric nervous system derived neurospheres. Front Cell Dev Biol. 2023 Jun 12; 11:1196472. doi:10.3389/fcell.2023.1196472.
Quintana D, Bounds HA, Brown J, Wang M, Bhatla N, Wiegert JS, Adesnik H. Dissociating instructive from permissive roles of brain circuits with reversible neural activity manipulations. bioRxiv. 2023 May 12:2023.05.11.540397. doi: 10.1101/2023.05.11.540397.
Bergs ACF, Liewald JF, Rodriguez-Rozada S, Liu Q, Wirt C, Bessel A, Zeitzschel N, Durmaz H, Nozownik A, Dill H, Jospin M, Vierock J, Bargmann CI, Hegemann P, Wiegert JS, Gottschalk A. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals. Nat Commun. 2023 Apr 6;14(1):1939. doi: 10.1038/s41467-023-37622-6.
Formozov A, Dieter A, Wiegert JS. A flexible and versatile system for multi-color fiber photometry and optogenetic manipulation. Cell Rep Methods. 2023 Mar 7;3(3):100418. doi: 10.1016/j.crmeth.2023.100418.
2022
Anisimova M., van Bommel B., Wiegert J.S., Mikhaylova M., Oertner T.G., Gee C.E. Spike-timing-dependent plasticity rewards synchrony rather than causality. Cereb Cortex. 2022 Dec 15;33(1):23-34. doi: 10.1093/cercor/bhac050.
Kubitschke, M., Mueller, M., Wallhorn, L., Pulin, M., Mittag, M., Pollok, S., Ziebarth, T., Bremshey, S., Gerdey, J., Claussen, K.C., Renken, K., Gross, J., Meyer, N., Wiegert, J.S., Reiner, A., Fuhrmann, M., Masseck, O.A. (2022) sDarken: Next generation genetically encoded fluorescent sensors for serotonin. Accepted at Nat Commun 2022 Dec 6;13(1):7525 doi: 10.1101/2022.03.10.483799.
Dürst, C., Wiegert, J.S., Schulze, C., Helassa, N., Török, K., Oertner, T.G. The vesicular release probability sets the strength of individual Schaffer collateral synapses. Nat Commun 2022 Oct 17;13(1):6126. doi: 10.1038/s41467-022-33565-6.
Stüdemann, T., Roessinger, J., Manthey, C., Geertz, B., Srikantharajah, R., von Bibra, C.C., Shibamiya, A., Koehne, M., Wiehler, A., Wiegert, J.S., Eschenhagen, T., Weinberger, F. (2021). Contractile force of transplanted cardiomyocytes contributes to heart function after injury. Circulation 2022 Oct 11;146(15):1159-1169. doi.:10.1161/CIRCULATIONAHA.122.060124.
Rodriguez-Rozada, S., Wietek, J., Tenedini, F. M., Sauter, K., Hegemann, P., Soba, P., & Wiegert, J.S. (2022). Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing. Commun Biol. 2022 Jul 9;5(1):687 doi: 10.1038/s42003-022-03636-x.
Fabarius A, Samra V, Drews O, Mörz H, Bierbaum M, Darwich A, Weiss C, Brendel S, Kleiner H, Seifarth W, Greffrath W, Hofmann WK, Schmitt CA, Popp HD. Evidence for Recombinant GRP78, CALR, PDIA3 and GPI as Mediators of Genetic Instability in Human CD34+ Cells. Cancers (Basel). 2022 Jun 11;14(12):2883. DOI: 10.3390/cancers14122883
Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P, Bruegmann T. Selective optogenetic control of Gq signaling using human Neuropsin. Nat Commun. 2022 Apr 1;13(1):1765. doi: 10.1038/s41467-022-29265-w.
Formozov, A., Chini, M., Dieter, A., Yang, W., Pöpplau, J., Hanganu-Opatz, I.L., Wiegert, J.S. Calcium imaging and electrophysiology of hippocampal activity under anesthesia and natural sleep in mice. Sci Data. 2022 Mar 29;9(1):113 doi: 10.1038/s41597-022-01244-2.
Wissing, C., Maheu, M., Wiegert, J.S., and Dieter, A. (2022). Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies. bioRxiv 2022 January 23. https://doi.org/10.1101/2022.01.22.477348.
Pulin, M., Stockhausen, K.E., Masseck, O.A., Kubitschke, M., Busse, B., Wiegert, J.S., and Oertner, T.G. (2022). Improved two-photon imaging of GPCR-based optogenetic neurotransmitter sensors using orthogonally polarized excitation. Biomed Opt. Express 2022 Jan 14;13(2): 777-790. doi: 10.1101/2021.11.15.468606.
2021
Imambocus, B.N., Zhou, F., Formozov, A., Wittich, A., Tenedini, F.M., Hu, C., Sauter, K., Varela, E.M., Herédia, F., Casimiro, A.P., Schlegel, P., Yang, C.H., Miguel-Aliaga, I., Wiegert, J.S., Pankratz, M.J., Gontijo, A.M., Cardona, A., Soba, P. (2022) Discrete escape responses are generated by neuropeptide-mediated circuit logic. Curr Biol. 2022 Jan 10;32(1):149-163.e8 doi: 10.1101/2020.09.22.307033.
*Vierock, J., *Rodriguez-Rozada, S., Dieter, A., Pieper, F., Sims, R., Tenedini, F., Bergs, A.C.F., Bendifallah, I., Zhou, F., Zeitzschel, N., Ahlbeck, J., Augustin S., Sauter, K., Papagiakoumou, E., Gottschalk, A., Soba, P., Emiliani, V., Engel, A.K., Hegemann, P., Wiegert, J.S. (2021). BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons. Nat Commun. 2021 Jul 26; 12, 4527. doi: 10.1038/s41467-021-24759-5. * equal contributions
*Yang, W., *Chini, M., Poepplau, J.A., Formozov, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu-Opatz, I.L., Wiegert, J.S. (2021). Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. PLOS Biol. 2021 Apr 1;19(4): e3001146. doi: 10.1371/journal.pbio.3001146. * equal contributions
*Mahn, M., *Saraf-Sinik, I., *Patil, P., *Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S., Yizhar, O. (2021). Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin. Neuron 2021 May 19;109 (10). doi: 10.1016/j.neuron.2021.03.013. * equal contributions
2020
Westermann, L. M., Fleischhauer, L., Vogel, J., Jenei-Lanzl, Z., Floriano Ludwig, N., Schau, L., Morellini, F., Baranowsky, A., Yorgan, T. A., Di Lorenzo, G., Schweizer, M., de Souza Pinheiro, B., Guarany, N. R., Sperb-Ludwig, F., Visioli, F., Oliveira Silva, T., Soul, J., Hendrickx, G., Wiegert, J. S., Schwartz, I. V. D., Clausen-Schaumann, H., Zaucke, F., Schinke, T., Pohl, S. and Danyukova, T. Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma. Dis Model Mech. 2020 Nov 18;13(11) doi: 10.1242/dmm.046425.
Perez-Alvarez, A., Fearey, B., Schulze, C., O'Toole, R.J., Moeyaert, B., Mohr, M.A., Arganda-Carreras, I., Yang, W., Wiegert, J.S., Schreiter, E.R., Gee, C.E., Hoppa, M.B., Oertner, T.G., (2020). Freeze-frame imaging of synaptic activity using SynTagMA. Nat Commun. 2020 May 18; 11(1): 2464, doi: 10.1038/s41467-020-16315-4.
2019
Binder, S., Molle, M., Lippert, M., Bruder, R., Aksamaz, S., Ohl, F., Wiegert, J.S., and Marshall, L. Monosynaptic hippocampal-prefrontal projections contribute to spatial memory consolidation in mice. J Neurosci 2019 Aug 28;39(35):6978-6991. doi:10.1523/JNEUROSCI.2158-18.2019.
Oppermann, J., Fischer, P., Silapetere, A., Liepe, B., Rodriguez-Rozada, S., Flores-Uribe, J., Peter, E., Keidel, A., Vierock, J., Kaufmann, J., Broser, M., Luck, M., Bartl, F., Hildebrandt, P., Wiegert, J. S., Béjà, O., Hegemann, P., and Wietek, J., (2019). MerMAIDs: A novel family of metagenomically discovered, marine, anion-conducting and intensely desensitizing Channelrhodopsins. Nat Commun. 2019 Jul 25; 10(1):3315, doi: 10.1038/s41467-019-11322-6.
Yizhar, O. & Wiegert, J. S. Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics. Trends Pharmacol Sci. 2019 Juni; 40(6):362-364 doi:10.1016/j.tips.2019.04.010.
Dürst, C., Wiegert, J.S., Helassa, N. Kerruth, S., Coates, C., Schulze, C., Geeves, M., Török, K., Oertner, T. G. (2019). High-speed imaging of glutamate release with genetically encoded sensors. Nat Prot. 2019 May; 14(5):1401-1424 doi:10.1038/s41596-019-0143-9.
2018
Wiegert, J.S., Pulin, M., Gee, C.E., Oertner, T. G. (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife. 2018 Oct 12:7:e39151 doi: 10.7554/eLife.39151.
Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun. 2018 Sep 26;9(1):3949 doi: 10.1038/s41467-018-06421-9.
Helassa, N., Dürst, C.D., Coates, C., Arif, U., Schulze, C., Wiegert, J.S., Geeves, M., Oertner, T.G., Török, K. (2018). Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses, Proc Natl Acad Sci USA 2018 May 22;115(21), 5594-5599 doi: 10.1073/pnas.1720648115.
2017
Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T.G., Soba, P., Hegemann, P., Wiegert, J.S. (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep. 2017 Nov 2;7:14957 doi: 10.1038/s41598-017-14330-y.
Wiegert, J. S., Mahn, M., Prigge, M. Prinz, Y., Yizhar, O. (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 2017 Aug 2;95 (3), 504-529 doi: 10.1016/j.neuron.2017.06.050.
Bitzenhofer, S.H., Ahlbeck, J., Wolff, A. Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Commun 2017 Feb 20;8:14563 doi: 10.1038/ncomms14563.
Wiegert, J.S., Gee, C.E., and Oertner, T. G. Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels. Cold Spring Harb Protoc. 2017 Feb 1;(2) doi: 10.1101/pdb.top089714.
Gee, C.E., Ohmert, I., Wiegert, J. S., and Oertner, T. G. Preparation of Slice Cultures from Rodent Hippocampus. Cold Spring Harb Protoc. 2017 Feb 1;(2) doi: 10.1101/pdb.prot094888.
Wiegert, J.S., Gee, C.E., and Oertner, T. G. Single-Cell Electroporation of Neurons. Cold Spring Harb Protoc 2017 Feb 1; (2) doi: 10.1101/pdb.prot094904.
Wiegert, J.S., Gee, C.E., and Oertner, T. G. Viral Vector-Based Transduction of Slice Cultures. Cold Spring Harb Protoc 2017 Feb 1;(2) doi: 10.1101/pdb.prot094896.
2016
Wiegert, J.S. and Oertner, T.G. How (not) to silence long-range projections with light. Nat Neurosci. 2016 Apr;19, 527-528. doi: 10.1038/nn.4270.
2015
Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep. 2015 Oct 7;5:14807 doi: 10.1038/srep14807.
Wiegert, J.S. and Oertner, T.G. Neighborly synapses help each other out. Nat Neurosci. 2015 Mar;18, 326-327. doi: 10.1038/nn.3955.
Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Vetter, T., Oertner, T.G. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal. 2015 Jan;19(1), 87-97 doi: 10.1016/j.media.2014.09.004.
2014
Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. Conversion of Channelrhodopsin into a light-gated chloride channel. Science 2014 Apr 25;344 (6182): 409-412, *first 2 authors equally contributing doi: 10.1126/science.1249375.
Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun. 2014 Jan 16;5:3024 doi: 10.1038/ncomms4024.
2013
Wiegert, J.S. and Oertner, T. G. Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 2013 Nov 19;110(47), E4510-E4519. doi: 10.1073/pnas.1315926110
2012
Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 2012 Apr 26; 484, 473-478. doi: 10.1038/nature11039
2011
Wiegert, J.S. and Bading, H. Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 2011 May;49, 296-305. doi: 10.1016/j.ceca.2010.11.009
Queisser, G., Wiegert, J.S., Bading, H. Structural dynamics of the cell nucleus: basis for morphology modulation of nuclear calcium signaling and gene transcription. Nucleus 2011 Mar-Apr; 2(2), 1-7. doi: 10.4161/nucl.2.2.15116
Wiegert, J.S. and Oertner, T. G. (2011). Shapeshifting for memory. e-Neuroforum 2011 2(1), 6-12. doi: 10.1007/s13295-011-0014-5
2010
Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 2010 Sep 7;107(36), 15975-15980. doi: 10.1073/pnas.1004562107.
2009
Wittmann, M. *, Queisser, G. *, Eder, A. *, Wiegert, J.S. *, Bengtson, C.P. *, Hellwig, A. *, Wittum, G., and Bading, H. Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci. 2009 Nov 25;29, 14687-14700. *first 6 authors equally contributing doi: 10.1523/jneurosci.1160-09.2009.
Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci. 2009; 10, 124. doi: 10.1186/1471-2202-10-124.
2007
Wiegert, J.S., Bengtson, C.P., and Bading, H. Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem. 2007 Oct 5; 282, 29621-29633. doi: 10.1074/jbc.m701448200y
