Publications

2024

Falkner F, Mayer SA, Heuer M, Brune J, Helt H, Bigdeli AK, Dimmler A, Heimel P, Thiele W, Sleeman JP, Bergmeister H, Schneider KH, Kneser U, Thomas B. Comparison of Decellularized Human Dermal Scaffolds versus Bovine Collagen/Elastin Matrices for Engineering of Soft-Tissue Flaps. Plast Reconstr Surg. 2024 Jan 1;153(1):130-141.

2023

Grube M, Dimmler A, Schmaus A, Saup R, Wagner T, Garvalov BK, Sleeman JP, Thiele W. Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice. Clin Exp Metastasis. 2023 Dec 9. doi: 10.1007/s10585-023-10249-z. Epub ahead of print. PMID: 38066243.

Deo A, Sleeman JP, Shaked Y. The role of host response to chemotherapy: resistance, metastasis and clinical implications. Clin Exp Metastasis. 2023 Nov 24. doi: 10.1007/s10585-023-10243-5. Epub ahead of print. PMID: 37999904.

Haier J, Sleeman J. Congratulations to Prof. em. Garth L. Nicolson - co-founder of Clinical & Experimental Metastasis. Clin Exp Metastasis. 2023 Dec;40(6):443-444.

Albrecht M, Sticht C, Wagner T, Hettler SA, De La Torre C, Qiu J, Gretz N, Albrecht T, Yard B, Sleeman JP, Garvalov BK. The crosstalk between glomerular endothelial cells and podocytes controls their responses to metabolic stimuli in diabetic nephropathy. Sci Rep. 2023 Oct 20;13(1):17985.

Saup R, Nair N, Shen J, Schmaus A, Thiele W, Garvalov BK, Sleeman JP. Increased Circulating Osteopontin Levels Promote Primary Tumour Growth, but Do Not Induce Metastasis in Melanoma. Biomedicines. 2023 Mar 28;11(4):1038.

Cotarelo CL, Schad A, Schmidt M, Hönig A, Sleeman JP, Thaler S. Detection of Cellular Senescence Reveals the Existence of Senescent Tumor Cells within Invasive Breast Carcinomas and Related Metastases. Cancers (Basel). 2023 Mar 20;15(6):1860.

Falkner F, Mayer SA, Thomas B, Zimmermann SO, Walter S, Heimel P, Thiele W, Sleeman JP, Bigdeli AK, Kiss H, Podesser BK, Kneser U, Bergmeister H, Schneider KH. Acellular Human Placenta Small-Diameter Vessels as a Favorable Source of Super-Microsurgical Vascular Replacements: A Proof of Concept. Bioengineering (Basel). 2023 Mar 7;10(3):337.

Sleeman JP. Therapy resistance and metastasis. Clin Exp Metastasis. 2023 Apr;40(2):123-124.

Thomas B, Warszawski J, Falkner F, Bleichert S, Haug V, Bigdeli AK, Schulte M, Hoffmann SHL, Garvalov BK, Schreiber C, Takamiya M, Sleeman JP, Schmidt VJ, Kneser U, Pichler BJ, Dimmler A, Thiele W. Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study. Plast Reconstr Surg. 2023 Jul 1;152(1):96e-109e.

Spataro S, Guerra C, Cavalli A, Sgrignani J, Sleeman J, Poulain L, Boland A, Scapozza L, Moll S, Prunotto M. CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease. FEBS J. 2023 Aug;290(16):3946-3962.

2022

Domanegg K, Sleeman JP, Schmaus A. CEMIP, a Promising Biomarker That Promotes the Progression and Metastasis of Colorectal and Other Types of Cancer.
Cancers (Basel). 2022 Oct 18;14(20):5093.

Schmaus A, Rothley M, Schreiber C, Möller S, Roßwag S, Franz S, Garvalov BK, Thiele W, Spataro S, Herskind C, Prunotto M, Anderegg U, Schnabelrauch M, Sleeman J. Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts.
Matrix Biol. 2022 May;109:173-191.

Schreiber C, Gruber A, Roßwag S, Saraswati S, Harkins S, Thiele W, Foroushani ZH, Munding N, Schmaus A, Rothley M, Dimmler A, Tanaka M, Garvalov BK, Sleeman JP. Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis. Cancer Lett.
2022 May 1;533:215600.

Leong SP, Witz IP, Sagi-Assif O, Izraely S, Sleeman J, Piening B, Fox BA, Bifulco CB, Martini R, Newman L, Davis M, Sanders LM, Haussler D, Vaske OM, Witte M. Cancer microenvironment and genomics: evolution in process. Clin Exp
Metastasis. 2022 Feb;39(1):85-99.

2021

Sedlmeier, G., Al‐Rawi, V., Buchert, J., Yserentant, K., Rothley, M., Steshina, A., Gräßle, S., Wu, R.‐L., Hurrle, T., Richer, W., Decraene, C., Thiele, W., Utikal, J., Abuillan, W., Tanaka, M., Herten, D.‐P., Hill, C.S., Garvalov, B.K., Jung, N., Bräse, S. and Sleeman, J.P. (2021). Id1 and Id3 Are Regulated Through Matrix‐Assisted Autocrine BMP Signaling and Represent Therapeutic Targets in Melanoma. Adv. Therap. 2000065. DOI:10.1002/adtp.202000065

Cotarelo CL, Zschöck-Manus A, Schmidt M, Schad A, Brochhausen C, Kirkpatrick CJ, Thaler S. (2021). Improved detection of sentinel lymph node metastases allows reliable intraoperative identification of patients with extended axillary lymph node involvement in early breast cancer. Clin Exp Metastasis 38(1):61-72

Roßwag S, Cotarelo CL, Pantel K, Riethdorf S, Sleeman JP, Schmidt M, Thaler S. (2021). Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2- Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2- Breast Cancer. Cancers (Basel). 13(8): 810

Kyjacova L, Saup R, Rönsch K, Wallbaum S, Dukowic-Schulze S, Foss A, Scherer SD, Rothley M, Neeb A, Grau N, Thiele W, Thaler S, Cremers N, Sticht C, Gretz N, Garvalov BK, Utikal J, Sleeman JP (2021). IER2-induced senescence drives melanoma invasion through osteopontin. Oncogene Nov;40(47):6494-6512.

Roßwag S, Sleeman JP, Thaler S. (2021).RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERα)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2. Cells 10(11):2868.

Kyjacova L, Saup R, Rothley M, Schmaus A, Wagner T, Boßerhoff A, Garvalov BK, Thiele W, Sleeman JP. (2021). Quantitative Detection of Disseminated Melanoma Cells by Trp-1 Transcript Analysis Reveals Stochastic Distribution of Pulmonary Metastases. J Clin Med. 10(22):5459.

2020

Haier J, Sleeman J, Schäfers J. (2020) Guidance of healthcare development for metastatic cancer patients as an example for setting incentives. Clin Exp Metastasis 37 :1-5

Foss A, Muñoz-Sagredo L, Sleeman J, Thiele W. (2020) The contribution of platelets to intravascular arrest, extravasation, and outgrowth of disseminated tumor cells. Clin Exp Metastasis 37: 47-67

Nwosu ZC, Piorońska W, Battello N, Zimmer AD, Dewidar B, Han M, Pereira S, Blagojevic B, Castven D, Charlestin V, Holenya P, Lochead J, De La Torre C, Gretz N, Sajjakulnukit P, Zhang L, Ward MH, Marquardt JU, di Magliano MP, Lyssiotis CA, Sleeman J, Wölfl S, Ebert MP, Meyer C, Hofmann U, Dooley S. (2020). Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance. EBioMedicine 54:102699.

Haier J, Sleeman J, Schäfers J. (2020). Assessment of incentivizing effects for cancer care frameworks. Clin Exp Metastasis 37(4):447-450

Haier J, Sleeman J, Schäfers J. (2020). Sociocultural incentives for cancer care implementation. Clin Exp Metastasis 37(5):561-563.

Hippe A, Braun SA, Oláh P, Gerber PA, Schorr A, Seeliger S, Holtz S, Jannasch K, Pivarcsi A, Buhren B, Schrumpf H, Kislat A, Bünemann E, Steinhoff M, Fischer J, Lira SA, Boukamp P, Hevezi P, Stoecklein NH, Hoffmann T, Alves F, Sleeman J, Bauer T, Klufa J, Amberg N, Sibilia M, Zlotnik A, Müller-Homey A, Homey B. (2020). EGFR/Ras-induced CCL20 production modulates the tumour microenvironment. Br J Cancer. 123(6):942-954.

Funck F, Pahl J, Kyjacova L, Freund L, Oehrl S, Gräbe G, Pezer S, Hassel JC, Sleeman J, Cerwenka A, Schäkel K. (2020). Human innate immune cell crosstalk induces melanoma cell senescence. Oncoimmunology 9(1):1808424.

Roßwag S, Thiede G, Sleeman JP, Thaler S. (2020). RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A). Cancers (Basel) 12(9):2689.

Sun Q, Picascia T, Khan AUM, Brenna C, Heuveline V, Schmaus A, Sleeman JP, Gretz N. (2020). Application of ethyl cinnamate based optical tissue clearing and expansion microscopy combined with retrograde perfusion for 3D lung imaging. Exp Lung Res. 46(10):393-408

Koch C, Kuske A, Joosse SA, Yigit G, Sflomos G, Thaler S, Smit DJ, Werner S, Borgmann K, Gärtner S, Mossahebi Mohammadi P, Battista L, Cayrefourcq L, Altmüller J, Salinas-Riester G, Raithatha K, Zibat A, Goy Y, Ott L, Bartkowiak K, Tan TZ, Zhou Q, Speicher MR, Müller V, Gorges TM, Jücker M, Thiery JP, Brisken C, Riethdorf S, Alix-Panabières C, Pantel K. (2020). Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity. EMBO Mol Med. 12(9):e11908.

2019

Voglstaetter M, Thomsen AR, Nouvel J, Koch A, Navarro EG, Gainey-Schleicher T, Khanduri R, Groß A, Rossner F, Blaue C, Franz CM, Veil M, Puetz G, Hippe A, Dindorf J, Kashef J, Thiele W, Homey B, Greco C, Boucheix C, Baur A, Erbes T, Waller CF, Follo M, Hossein G, Sers C, Sleeman J, Nazarenko I. (2019). Tspan8 is expressed in breast cancer and regulates E-cadherin / catenin signalling and metastasis accompanied by increased circulating extracellular vesicles. J Pathology 248(4):421-437

Schreiber C, Saraswati S, Harkins S, Gruber A, Cremers N, Thiele W, Rothley M, Plaumann D, Korn C, Armant O, Augustin HG, Sleeman JP. (2019) Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling. PLoS Genetics, 15(6):e1008216

Thiele W, Kyjacova L, Köhler A, Sleeman JP. (2019) A cautionary note: Toxicity of polyethylene glycol 200 injected intraperitoneally into mice. Lab Anim. [Epub ahead of print]

Grau N, Scherer SD, Rothley M, Roßwag S, Thiele W, Stoecklein NH, Cremers N, Thaler S, Garvalov BK, Sleeman JP. (2019) Spatiotemporally controlled induction of gene  expression in vivo allows tracking the fate of tumor cells that traffic through the lymphatics. Int J Cancer [Epub ahead of  print]

Haier J, Sleeman J, Schäfers J. (2019) Editorial series: cancer care in low- and middle-income countries. Clin Exp Metastasis 36: 477-480

Albrecht T, Rausch M, Roessler S, Albrecht M, Braun JD, Geissler V, Mehrabi A, Vogel NM, Pathil-Warth A, Mechtersheimer G, Renner M, Rupp C, Weiss KH, Busch E, Köhler B, Springfeld C, Schirmacher P, Goeppert B. (2019) HER2 gene (ERBB2) amplification is a rare event in non-liver fluke associated cholangiocarcinogenesis. BMC Cancer 19: 1191

Albrecht T, Rausch M, Roessler S, Geissler V, Albrecht M, Halske C, Seifert C, Renner M, Singer S, Mehrabi A, Vogel MN, Pathil-Warth A, Busch E, Köhler B, Rupp C, Weiss KH, Springfeld C, Röcken C, Schirmacher P, Goeppert B. (2019) HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma. Virchows Arch [Epub ahead of  print]

Aly AA, El-Sheref EM, Bakheet MEM, Mourad MAE, Bräse S, Ibrahim MAA, Nieger M, Garvalov BK, Dalby KN, Kaoud TS. (2019) Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma. Bioorg Chem 82: 290-305

Beadnell T, Borriello L, Christenson J, Fornetti J, Guldner I, Hanna A, Kyjacova L, Marinak-Whately K, de Melo Martins PC, Rotinen M, Te Boekhorst V, Cox TR. (2019) Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis. Clin Exp Metastasis 36: 119-137

Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG. (2019) LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer. Int J Cancer 145:901-915

Garvalov BK, Muhammad S, Dobreva G. Lamin B1 in cancer and aging. (2019) Aging (Albany NY) 11: 7336-7338

Jia Y, Vong JS, Asafova A, Garvalov BK, Caputo L, Cordero J, Singh A, Boettger T, Gunther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R, Dobreva G. (2019) Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET. J Exp Med 216: 1377-1395

Pan C, Schoppe O, Parra-Damas A, Cai R, Todorov MI, Gondi G, von Neubeck B, Böğürcü-Seidel N, Seidel S, Sleiman K, Veltkamp C, Förstera B, Mai H, Rong Z, Trompak O, Ghasemigharagoz A, Reimer MA, Cuesta AM, Coronel J, Jeremias I, Saur D, Acker-Palmer A, Acker T, Garvalov BK, Menze B, Zeidler R, Ertürk A. (2019) Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body. Cell 179: 1661-1676

2018

Bauer J, Rothley M, Schmaus A, Quagliata L, Ehret M, Biskup M, Orian-Rousseau V, Jackson DG, Pettis RJ, Harvey A, Bräse S, Thiele W and Sleeman JP. (2018). TGFβ counteracts LYVE-1-mediated induction of lymphangiogenesis by small hyaluronan oligosaccharides. J Mol Med (Berl) 96:199-209

Antoni C, McDuffie Y, Bauer J, Sleeman JP and Boehm H (2018). Matrix model for lymphangiogenesis: co-presentation of adhesive ligands and short hyaluronan. Frontiers in Bioengineering and Biotechnology, 6: 25

Veselkov K, Sleeman JP, Claude E, Vissers J, Galea D, Mroz A, Laponogov I, Towers M, Tonge R, Mirnezami R, Takats Z, Nicholson J and Langridge J (2018). BASIS: High-performance bioinformatics platform for processing of large-scale mass spectrometry imaging data in chemically augmented histology. Scientific Reports 8: 4053

Nwosu ZC, Battello N, Rothley M, Piorońska W, Sitek B, Ebert MP, Hofmann U, Sleeman J, Wölfl S, Meyer C, Megger DA and Dooley S (2018). Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours. J Exp Clin Cancer Res. 37:211

Araos J, Sleeman JP and Garvalov BK (2018). The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies. Clin Exp Metastasis 35: 563-599

Thiele W, Rothley M, Dimmler A, Bugert P, Salomó Coll C and Sleeman JP (2018). Platelet deficiency in Tpo(-/-) mice can both promote and suppress the metastasis of experimental breast tumors in an organ-specific manner. Clin Exp Metastasis 35: 679-689

Wu R*, Sedlmeier G*, Kyjacova L, Schmaus A, Philipp J, Thiele W, Garvalov BK and Sleeman JP (2018). Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells. Scientific Reports 8: 14913. *Equal contribution

Sleeman JP (2018). Dietary control of metastasis. Clin Exp Metastasis 35: 713-4

Böğürcü N, Seidel S, Garvalov BK*, Acker T*. (2018) Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts. Methods Mol Biol 1742: 283-300. *Equal contribution

Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford JR, Kohlhof P, Kristensen BW, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Mühleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo NG, Driever PH, Kramm CM, Müller HL, Rutkowski S, von Hoff K, Frühwald MC, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu CM, Perry A, Jones C, Jacques TS, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins VP, Blümcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott PA, Paulus W, Gajjar A, Robinson GW, Taylor MD, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis MA, Mittelbronn M, Acker T, Hartmann C, Aldape K, Schüller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison DW, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister SM. (2018) DNA methylation-based classification of central nervous system tumours. Nature 555: 469-474

Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK*, Acker T*. (2018) PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα. Cancer Res 78: 1805-1819. *Equal contribution

Haslinger D, Waltes R, Yousaf A, Lindlar S, Schneider I, Lim CK, Tsai MM, Garvalov BK, Acker-Palmer A, Krezdorn N, Rotter B, Acker T, Guillemin GJ, Fulda S, Freitag CM, Chiocchetti AG. (2018) Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model. Mol Autism 9: 56

Schänzer A, Rupp S, Graf S, Zengeler D, Jux C, Akintürk H, Gulatz L, Mazhari N, Acker T, Van Coster R, Garvalov BK*, Hahn A*. (2018) Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3. Mol Genet Metab 123: 388-399. *Equal contribution

2017

Sedlmeier, G. and Sleeman, J. P. (2017). Extracellular regulation of BMP signaling: Welcome to the matrix. Biochemical Society Transactions 45: 173-181

Stott SR, Hayat S, Carnwath T, Garas S, Sleeman JP, Barker RA (2017). CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease. PLoS One 12: e0171748

Sleeman J. P. (2017) Editorial: special issue introduction. Clin Exp Metastasis 34: 197-198

Sleeman J. P. (2017). PIPAC puts pressure on peritoneal metastases from pancreatic cancer. Clin Exp Metastasis 34(5):291-293

Li, J., Kwiatkowska, B., Lu, H., Voglstätter, M., Ueda, E., Grunze, M., Sleeman, J. P., Levkin, P., Nazarenko, I. (2017). Collaborative action of surface chemistry and topography in the regulation of mesenchymal and epithelial markers and the shape of cancer cells. ACS Applied Materials & Interfaces, 8(42):28554-28565

Thaler, S., Schmidt, M., Roßwag, S., Thiede, G., Schad, S., and Sleeman, J. P. (2017). Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells. Oncotarget, 8(42):72281-72301

2016

Seidl C, Ungelenk J, Zittel E, Bergfeldt T, Sleeman JP, Schepers U, and Feldmann C. (2016). Tin Tungstate Nanoparticles: A Photosensitizer for Photodynamic Tumor Therapy. ACS Nano 10(3):3149-57.

Krachulec, J., Sedelmeier G., Thiele, W. and Sleeman, J.P. (2016). Footprintless disruption of pro-survival genes in aneuploid cancer cells using CRISPR/Cas9 technology. Biochemistry and Cell Biology, 94(3):289-96

Cremers, N., Neeb, A., Uhle, T., Dimmler, A., Rothley, M., Allgayer, H., Fodde, R., Sleeman, J. P. and Thiele, W. (2016). CD24 is not required for tumor initiation and growth in murine breast and prostate cancer models. PLoS One, 11: e0151468

Scherer SD, Bauer J, Schmaus A, Neumaier C, Herskind C, Veldwijk MR, Wenz F, Sleeman JP. (2016). TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT). PLoS One. 11(9):e0162221

Cotarelo CL, Schad A, Kirkpatrick CJ, Sleeman JP, Springer E, Schmidt M, and Thaler S. (2016). Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes. Oncotarget 7: 74846-74859

Alishekevitz, D., Gingis-Velitski, S., Kaidar-Person, O., Gutter-Kapon, L., Scherer, S., Merquiol, E., Yael Ben-Nun, Y., Miller, V., Rachman, C., Timaner, M., Mumblat, Y., Raviv, Z., Ilan, N., Loven, D., Satchi-Fainaro, R., Blum, G., Sleeman, J. P., Vlodavsky, I. and Shaked, Y. (2016). Macrophage-induced lymphangiogenesis and metastasis following paclitaxel chemotherapy is regulated by VEGFR-3. Cell Reports 17: 1344-1356

Barkan, D., Abu-Tayeh, H., Weidenfeld, J., Zhilin-Roth, A., Schif-Zuck, S., Thaler, S., Cotarelo, C., Tan, T., Thiery, J.P., Green, J.E., Klorin, G., Sabo, E., Sleeman, J.P. and Tzukerman, M. (2016). 'Normalizing' the Malignant Phenotype of Luminal Breast Cancer Cells via Alpha(V)Beta(3)-Integrin. Cell Death and Disease 7 :e2491

Sleeman JP. (2016). Introduction of revised "Aims and Scope" for Clinical & Experimental Metastasis. Clin Exp Metastasis 33: 741-742

Hanke-Roos M, Fuchs K, Maleschlijski S, Sleeman J, Orian-Rousseau V, Rosenhahn A. (2016) CD44 mediates the Catch-Bond Activated Rolling of HEPG2 Epithelial Cancer Cells on Hyaluronan. Cell Adh Migr 22:1-12

2015

Hansen, M., Forst, B., Cremers, N., Quagliata, L., Ambartsumian, N., Klingelhöfer, J., Stein, U., Nielsen, G., Scherer, P., Lukanidin, E., Sleeman, J.P.* and Grigorian, M.* (2015). A downstream target of the metastasis-promoting S100A4 protein, Serum Amyloid A is a potent inducer of tumor metastasis. Oncogene, 34: 424-35
* Equal contribution

Seubert B, Grünwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwälder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA and Krüger A. (2015). TIMP-1 creates a pre-metastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology, 61: 238-248

Schmaus, A. and Sleeman, J. P. (2015). Hyaluronidase-1 Expression Promotes Lung Metastasis in Syngeneic Mouse Tumor Models without Affecting Accumulation of Small Hyaluronan Oligosaccharides in Tumor Interstitial Fluid. Glycobiology, 25: 258-268.

Thaler, S., Thiede, G., Hengstler, J. G., Schad, A., Schmidt, M. and Sleeman, J. P. (2015) The proteasome inhibitor Bortezomib (Velcade) is an inhibitor of estrogen receptor-positive breast cancer. Int J. Cancer, 137: 686-97.

Mudduluru, G., Abba, M., Batliner, J., Patil, N., Scharp, M., Lunavat, TR., Leupold, J., Oleksiuk, O., Juraeva, D., Thiele, W., Rothley, M., Benner, A., Ben-Neriah, Y., Sleeman, J. and Allgayer, H. (2015). A Systematic Approach to Defining the microRNA Landscape in Metastasis. Cancer Research 75: 3010-9

Sleeman, J.P. (2015). Pre-metastatic conditioning of organ microenvironments by tumors:
beyond preparing the soil.  J Mol Med  93: 1171-2

Sleeman, J.P. (2015). The lymph node pre-metastatic niche. J Mol Med 93: 1173–1184

2014

Thiele, W., Rothley, M., Schmaus, A., Plaumann, D. and Sleeman, J. P. (2014). Flow cytometry-based isolation of lymphatic endothelial cells from newborn rats. Lymphology, 47: 177-86

Heckmann, D., Maier, P., Laufs, S., Li, L., Sleeman, J.P., Trunk, MJ., Leupold, JH., Wenz, F., Zeller, WJ., Fruehauf, S. and Allgayer, H. (2014). The disparate twins: A comparative study of CXCR4 and CXCR7 in SDF-1-induced gene expression,invasion and chemosensitivity of colon cancer. Clin Cancer Res, 20: 604-16

Quagliata, L., Klusmeier, S., Cremers, N., Pytowski, B., Harvey, A., Pettis, R., Thiele, W. and Sleeman, J. P.(2014). Lymph node lymphangiogenesis is required for lymph node but not lung metastasis formation in a syngeneic rat breast cancer model. Clin Exp Metastasis, 31: 351-65

Orian-Rousseau, V. and Sleeman, J.P. (2014). CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals. Adv. Cancer Res. 123: 231-354

Schmaus, A., Rothley, M., Dimmler, A., Sipos, B., Faller, G., Thiele, W., Allgayer, A., Hohenberger, P., Post, S. and Sleeman, J. P. (2014). Quantification of hyaluronan degradation products in tumor interstitial fluid. British J. Cancer., 111: 559-567.

Schmaus, A., Bauer, J. and Sleeman, J. P. (2014). Sugars in the microenvironment: The sticky problem of hyaluronan turnover in tumors. Cancer and Metastasis Reviews, 33: 1059-79

2013

Muppala, S., Mudduluru, G., Leupold, J. H., Buergy, D., Sleeman, J.P.* and Allgayer, H.* , (2013). CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a. PLoS One, 8: e59563
* Equal contribution

Schreiber, C, Kuch, V., Umansky, V. and Sleeman, J. P.  (2013). Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog. PLoS One, 8: e57465

Kuch, V., Schreiber, C, Thiele, W., Umansky, V. and Sleeman, J. P. (2013). Tumor initiating properties of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro, but can be increased by long-term culturing as adherent monolayers. Int. J. Cancer, 132: E94-105

Thiele, W., Rothley, M., Teller, N., Jung, N., Bulat, B., Plaumann, D., Vanderheiden, S., Schmaus, A., Cremers, C., Göppert, B., Dimmler, A., Eschbach, V., Quagliata, L., Thaler, S., Marko, D., Bräse and Sleeman, J. P.(2013). Delphinidin is a novel inhibitor of lymphangiogenesis, but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats. Carcinogenesis, 34: 2804-13

Quero, L., Klawitter, M., Schmaus, A., Rothley, M., Sleeman, J., Tiaden, A., Mirsaidi, A., Klasen, J., Boos, N., Hottiger, M., Wuertz, K. and Richards, P. (2013). Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of TLR2 signaling pathways. Arthritis Research & Therapy, 15: R94

Fuchs, K., Hippe, A., Schmaus, A., Homey, B., Sleeman, J.P. and Orian-Rousseau, V. (2013). Opposing effects of high and low molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44. Cell Death & Disease, 4: e819

2012

Sleeman, J.P., Cady, B., and Pantel, K. (2012). The connectivity of lymphogenous and hematogenous tumor cell dissemination: biological insights and clinical implications. Clin. Exp. Metastasis, 29: 737-746

Thiele, W., Krishnan, J., Rothley, M., Weih, D., Plaumann, D., Kuch, V., Quagliata, L., Weich, H. and Sleeman, J. P. (2012). VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis. Blood, 120: 1899-1907.

Sleeman, J.P. (2012). The metastatic niche and stromal progression. Cancer and Metastasis Reviews, 31: 429-440

Sleeman, J.P., Christofori, G., Fodde, R., Collard, J., Berx, G., Decraene, C. and Rüegg, C. (2012). Concepts of metastasis in flux: the stromal progression model. Seminars in Cancer Biology, 22: 174-186

Sleeman, J.P. (2012). Metastasis: Understanding is the beginning of order in chaos. Seminars in Cancer Biology,22: 173

Thaler, S., Schad, A., Schmidt, M. and Sleeman, J.P. (2012). RASSF1A inhibits estrogen receptor alpha expression and estrogen-independent signaling: implications for breast cancer development. Oncogene, 31: 4912-22

Neeb, A., Wallbaum, S., Novac, N., Scholl, I., Dukovic-Schulze, S., Schreiber, C., Schlag, P., Moll, J., Stein, U. and Sleeman, J. P.  (2012). The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal carcinoma patients. Oncogene, 31: 3796-3806

Baumann, P., Thiele, W., Cremers, N., Muppala, S., Krachulec, J., Diefenbacher, M., Kassel, O., Mudduluru, G., Allgayer, H., Frame, M. and Sleeman, J. P. (2012). CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion. Cell Mol Life Sci., 69: 435-448

Lukanidin, E. and Sleeman, J.P. (2012). Building the niche: The role of the S100 proteins in metastatic growth.Seminars in Cancer Biology, 22: 216-225

Euler T. and Hausselt S.E. (2012). Wie die Netzhaut die Richtung von Bewegungen berechnet (Computation of motion direction in the vertebrate retina) Neuroforum, 3/12: 234-245, DOI 10.1007/s13295-012-0033-x

Kaindl, T., Rieger, H., Kaschel, L., Engel, U., Schmaus, A., Sleeman, J.P.* and Tanaka, M.* (2012). Spatio-temporal patterns of pancreatic cancer cells expressing CD44 isoforms on supported membranes displaying hyaluronic acid oligomers arrayed with a defined distribution. PLoS One, 7: e42991
* Equal contribution

2011

Rana S, Claas C, Kretz CC, Nazarenko I, Zoeller M. (2011). Activation-induced internalization differs for the tetraspanins CD9 and Tspan8: Impact on tumor cell motility. Int J Biochem Cell Biol. 43: 106-19

Geyer FL, Ueda E, Liebel U, Grau N and Levkin PA. (2011). Superhydrophobic-Superhydrophilic Micropatterning: Towards Genome-on-a-Chip Cell Microarrays. Angew Chem Int Ed Engl. doi: 10.1002/anie.201102545

Neeb, A., Wallbaum, S., Novac, N., Scholl, I., Dukovic-Schulze, S., Schreiber, C., Schlag, P., Moll, J., Stein, U. and Sleeman, J. P. (2011). The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal carcinoma patients. Oncogene, doi: 10.1038/onc.2011.535

Sleeman, J.P., Nazarenko, I. and Thiele, W. (2011). Do all roads lead to Rome? Routes to metastasis development. Int. J. Cancer, 128: 2511-26

Witte, M.H., Dellinger, M.T., McDonald, D.M., Nathanson, S.D., Boccardo, F.M., Campisi, C.C.C., Sleeman, J.P. and Gershenwald, J.E. (2011). Lymphangiogenesis and Hemangiogenesis: Potential Targets for Therapy. J. Surg. Oncol., 103: 489-500

Sleeman, J.P. and Thiery, J.P. (2011). The epithelial-mesenchymal transition. Cell 145: 162.e1

Devitt-Moller, H., Ralfkjaer, U., Cremers, N., Frankel, M., Troelsgaard Pedersen, R., Klingelhöfer, J., Yanashigawa, H., Grigorian, M., Guldberg, P., Sleeman, J. P., Lukanidin, U. and Ambartsumian, N. (2011). Role of Fibulin-5 (FBLN5) in late stage metastasogenesis. Molecular Cancer Research, 9: 553-63

Thiele, W., Novac, N., Mink, S., Schreiber, C., Plaumann, D., Fritzmann, J., Schwager, C., Regiert, T., Huber, P. E., Stein, U., Schlag, P., Moll, J., Abdollahi, A. and Sleeman, J.P. (2011). Discovery of a novel tumor metastasis-promoting gene NVM-1.  J. Pathol., 225: 96-105

Kaufmann L, Marinescu G, Nazarenko I, Thiele W, Oberle C, Sleeman J and Blattner C. (2011). LiCl induces TNF-alpha and FasL production, thereby stimulating apoptosis in cancer cells. Cell Communication and Signalling, 9: 15.

2010

Virlouvet, M., Gartner, M., Koroniak, K., Sleeman, J.P., and Bräse, S. (2010). Multi-Gram Synthesis of a Hyaluronic Acid Subunit and Synthesis of Fully Protected Oligomers. Advanced Synthesis & Catalysis, 352: 2657-2662.

Cremers, N and Sleeman, J.P. (2010) Loss of CD24 expression promotes ductal branching and enhanced alveoli formation in the murine mammary gland. Cell Mol Life Sci., 67: 2311-2322
Sleeman, J. P. and Steeg, P. S. (2010) Cancer metastasis as a therapeutic target. European J. Cancer, 46: 1177-1180

Müller, T., Stein, U., Poletti, A., Garzia, L., Rothley, M., Plaumann, D., Thiele, W., Bauer, M., Galasso, A., Schlag, P., Pankratz, M., Zollo, M. and Sleeman, J. P. (2010). ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients. Oncogene, 29: 2393-2403

Sleeman, J. P. (2010). Understanding the mechanisms of lymphangiogenesis: a hope for cancer therapy? Phlebolymphology, 17: 99-107

Gebhardt, C., Averbeck, M., Diedenhofen, N., Willenberg, A., Anderegg, U., Sleeman, J.P. and Simon, J.C. (2010). Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J. Invest. Dermatol., 130: 141–149

2009

Thaler S, Hähnel PS, Schad A, Dammann R, Schuler M. (2009). RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt. Cancer Res., 69(5):1748-57

Teller, N., Thiele, W., Boettler, U., Sleeman, J. P. and Marko, D. (2009). Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Mol. Nutrition & Food Res., 53: 1075 - 1083

Sleeman, J. P. and Thiele, W. (2009). Tumor metastasis and the lymphatic vasculature. Int. J. Cancer, 125: 2747 - 2756

Sleeman, J. P., Schmid A. and Thiele, W. (2009). Tumor lymphatics. Semin. Cancer Biol. 19: 285 - 297

Steeg, P. S., Anderson, R. L., Bar-Eli, M., Chambers, A. F., Eccles, S. A., Hunter, K., Itoh, K., Kang, Y., Matrisian, L. M., Sleeman, J. P., Theodorescu, D., Thompson, E. W. and Welch, D. R. (2009). Preclinical drug development must consider the impact on metastasis. Clin. Cancer Res., 15: 4529-4530

Teller, N., Thiele, W., Marczylo, T, Gescher, A., Boettler, U., Sleeman, J. P. and Marko, D. (2009). Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin mixtures extracted from bilberries and grapes.  J. Agricultural and Food Chem., 57: 3094-3101.

Wallbaum, S., Grau, N., Schmid, A., Frick, K., Neeb, A. and Sleeman, J.P. (2009). Cell cycle quiescence suppresses transcription from an ecdysone receptor-based inducible promoter in mammalian cells. Biotechniques 46: 433 - 440

Rothley., M, Thiele, W., Schacht, V., Plaumann, D., Gartner, M., Giannis, A. and Sleeman, J.P. (2009). Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo. Int. J. Cancer 125: 34 - 42

Sleeman, J.P. and Neeb, A. (2009). Chapter 12. Tumor Lymphangiogenesis: What We Know and Don't Know. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites through the Lymphovascular System. Editor: Stanley P. L. Leong, M.D. Publisher: Springer. In press

Anderegg, U., Eichenberg, T., Parthaune, T., Haiduk, C., Saalbach, A., Milkova, L., Ludwig, A., Grosche, J., Averbeck, M., Gebhardt, C., Voelcker, V., Sleeman, J.P. and Simon J.C. (2009). ADAM10 Is the Constitutive Functional Sheddase of CD44 in Human Melanoma Cells. J Invest Dermatol. 129:1471-1482

2008

Voelcker, V., Gebhardt, C., Averbeck, M., Saalbach, A., Wolf, V., Weih, F., Sleeman, J. P., Anderegg, U. and Simon, J. C. (2008). Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells through TLR4. Exp. Dermatol. 17: 100-107.

Bruyère F, Melen-Lamalle L, Blacher S, Roland G, Thiry M, Moons L, Frankenne F, Carmeliet P, Alitalo K, Libert C, Sleeman JP, Foidart JM, Noël A. (2008). Modeling lymphangiogenesis in a three-dimensional culture system. Nat Methods 5: 431-437.

2007

Sleeman, J.P. and Cremers, N. (2007). New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment. Clinical and Experimental Metastasis 24: 707-715

Eccles, S., Paon, L. and Sleeman, J.P. (2007). Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms. Clinical and Experimental Metastasis 24: 619-636

Berx, G., Raspé, E., Christofori, G., Thiery, J.P. and Sleeman, J.P. (2007). Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clinical and Experimental Metastasis, 24: 587-597

Sleeman, J.P. (2007) The relationship between tumors and the lymphatics: consequences for metastasis. In: Tumor Angiogenesis, (Fusenig, N. and Marmé, D, Eds), Springer Verlag.

Averbeck, M., Gebhardt, C., Anderegg, U., Termeer, C., Sleeman, J.P. and Simon, J. C. (2007) Switch of Syndecan-1 and Syndecan-4 expression controls maturation-associated dendritic cell motility. Exp. Dermatol., 16: 580-589.

Averbeck, M., Gebhardt C., Voigt S., Beilharz S., Anderegg U., Termeer C., Sleeman, J. P. and Simon, J. C. (2007) Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiation. J. Invest. Dermatol., 127: 687-697

Saalbach, A., Klein, C., Sack, U., Anderegg, U., Kauer, F., Gebhardt, C., Averbeck, M., Sleeman, J. P. and Simon, J. C. (2007) Dermal fibroblasts induce maturation of dendritic cells. J.Immunology, 178: 4966-4974.

2000 - 2006

Sleeman, J. P. (2006). The relationship between tumors and the lymphatics: what more is there to know? Lymphology, 39: 62-68.

Thiele, W. and Sleeman, J. P. (2006). Tumor-induced lymphangiogenesis: a target for cancer therapy? J. Biotechnology, 124: 224-241.

Thiery, J. P. and Sleeman, J. P. (2006). Complex networks orchestrate epithelial-mesenchymal transitions. Nature Reviews Molecular Cell Biology, 7: 131-142

Baumann, P., Cremers, N., Kroese, F., Orend, G., Chiquet-Ehrismann, R., Uede, T., Yagita, H. and Sleeman, J. P. (2005). CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis. Cancer Research, 65: 10783-10793

Schempp, C. M., Kiss, J., Kirkin, V., Simon-Haarhaus, B., Kremer, B., Termeer, C., Sleeman, J. P. and Simon, J. C. (2005). Hyperforin acts as an angiogenesis inhibitor in vitro and in vivo. Planta Medica, 71: 999-1004

Gartner M., Müller T., Simon J.C., Giannis A., Sleeman J.P. (2005). Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent. Chembiochem, 6, 171-177.

Kirkin V., Thiele W., Baumann P., Mazitschek R., Rohde K., Fellbrich G., Weich H., Waltenberger J., Giannis A., Sleeman J.P. (2004). MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. Int. J. Cancer, 112, 986-993.

Mengwasser J., Piau A., Schlag P., Sleeman J.P. (2004). Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens. Oncogene, 23, 7430-7435.

Bando H., Brokelmann M., Toi M., Alitalo K., Sleeman J.P., Sipos B., Grone H.J., Weich H.A. (2004). Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues. Int. J. Cancer, 111, 184-191.

Fieber, C., Baumann, P., Vallon, R., Hofmann, M., Angel, P., Herrlich, P. and Sleeman, J. P. (2004). Hyaluron-oligosaccharide-induced transcription of metalloproteases. J. Cell Sci., 117, 359-367.

Van Trappen, P. O., Steele, D., Lowe, D. G., Baithun, S., Levey, P., Beasley, N., Thiele, W., Weich, H., Krishnan, J., Shepherd, J. H., Pepper, M. S., Jackson, D., Sleeman, J. P. and Jacobs, I. J. (2003).

Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis. J. Pathol., 201, 544-554.

Bosserhoff, A.-K., Stoll, R., Sleeman, J. P., Bataille, F., Buettner, R. and Holak, T. A. (2003). Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of MIA (melanoma inhibitory activity). Lab. Invest., 83, 1583-1594.

Termeer, C., Voith, U., Hara, M., Eibel, H., Sleeman, J. P. and Simon, J. C. (2003). Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS independent T-cell apoptotsis.  Immunology, 109, 32-40.

Tille, J. C., Wang, X., Lipson, K. E., McMahon, G., Ferrara, N., Zhu, Z., Hicklin, D. J., Sleeman, J. P., Eriksson, U., Alitalo, K. and Pepper, M. S. (2003). Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-CΔNΔC- and VEGF-A-induced angiogenesis in vitro. Exp. Cell Res., 285, 286-298.

Termeer, C., Sleeman, J. P. and Simon, J. C. (2003). Hyaluronan - magic glue for the regulation of the immune response? Trends in Immunology, 24, 112-114.

Krishnan, J., Kirkin, V., Steffen, A., Hegen, M., Weih, D., Tomarev, S., Wilting, J. and Sleeman, J. P. (2003). Differential in vivo and in vitro expression of VEGF-C and VEGF-D in tumors and its relationship to lymphatic metatasis in immunocompetent rats. Cancer Research, 63, 713-722.

Orian-Rousseau, V., Chen, L., Sleeman, J. P., Herrlich, P. and Ponta, H. (2002). Requirement for CD44 in two subsequent steps of HGF/c-Met signaling. Genes and Development, 16, 3087-3099.

Khaldoyanidi, S., Karakhanova, S., Sleeman, J.P., Herrlich, P. and Ponta, H. (2002). CD44 variant specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages. Blood, 99, 3955-3961.

Sleeman, J. P., Baumann, P., Novac, N., Thies, W.-G., Nestl, A., von Stein, O. and Hofmann, M. (2002). Genetik der Tumormetastasen. FZK Nachrichten, 34, 31-35.

Mengwasser J., Liu F.T., Sleeman J.P. (2002). Expression of Galectin-3 is strongly upregulated in non-apoptosing mammary epithelial cells during rat mammary gland involution. Glycobiology, 12, 129-134.

Schempp, C., Kirkin, V., Simon-Haarhaus, B., Kersten, A., Termeer, C., Gilb, B., Sleeman, J.P. and Simon, J. (2002). Inhibition of tumor growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene, 21, 1242-1250.

Göttlicher, M., Minucci, S., Zhu, P., Krämer, O., Schimpf, A., Giavara, S., Sleeman, J. P., Lo Coco, F., Nervi, C., Pelicci, P. and Heinzel, T. (2001). Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J., 20, 6969-6978.

Sleeman, J. P. (2001). Wie sicher ist genetisch verändertes Getreide? Naturschutzblätter, in press.

Kirkin, V., Mazitschek, R., Krishnan, J., Steffen, A., Waltenberger, J., Pepper, M.S., Giannis, A. and Sleeman, J.P. (2001). Characterisation of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. European Journal of Biochemistry, 268, 5530-5540.

Papoutsi, M., Sleeman, J.P., Wilting, J. (2001). Interaction of rat tumor cells with blood vessels and lymphatics of the avian chorioallantoic membrane. Microscopy Research and Technique, 55, 100-107.

Sleeman, J.P., Krishnan, J., Kirkin, V. and Baumann, P. (2001). Markers for the lymphatic endothelium: in search of the Holy Grail? Microscopy Research and Technique, 55, 61-69.

Sleeman, J. P., Novac, N., Thies, W.-G., Nestl, A., von Stein, O. and Hofmann, M. (2001). Molecular and cellular mechanisms of lymphogenic metastatic spread: underlying changes in gene expression patterns. In Proceedings of the 4th International Symposium on Metastases in Head and Neck Cancer: Advances in Experimental and Clinical Research (Ed. Werner, J.), pp 93-97.

Mengwasser, J. and Sleeman, J. P. (2001). Expression of M-N#1, a histo-blood group B-like antigen, is strongly upregulated in non-apoptosing mammary epithelial cells during rat mammary gland involution. Glycobiology, 11,441-449.

Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, M., Ponta, H., Herrlich, P., Simon, J.C. (2001). Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid.Oncogene, 20, 3399-3408.

Sleeman, J. P., Thies, W.-G., Nestl, A., von Stein, O. and Hofmann, M. (2001). Fact and Fiction: changing concepts in tumor metastasis. In The Sentinel Lymph Node Concept in Oncology - Facts and Fiction (Ed. Munz, D.). W. Zuckschwerdt Verlag, Berlin, pp 13-25

Nestl, A., Von Stein, O., Zatloukal, K., Thies, W.-G., Herrlich, P., Hofmann, M. and Sleeman, J. P. (2001). Gene expression patterns associated with the metastatic phenotype in rodent and human tumors. Cancer Research, 61, 1569-1577.

Herrlich, P., Morrison, H., Sleeman, J. P., Orian-Rousseau, V., König, H., Weg-Remmers, S. and Ponta, H.(2000). CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-supressing cofactor. Annals N. Y. Acad. Sci., 910, 106-120.

Hebbard, L., Steffen, A., Zawadski, V., Fieber, C., Howells, N., Moll, J., Ponta, H., Hofmann, M., and Sleeman, J.P. (2000). CD44v6 expression and regulation during mammary gland development and function: implications for mammary carcinogenesis. J. Cell Science, 113, 2619-2630.

Sleeman, J.P. (2000). The lymph node as a bridgehead in the metastatic dissemination of tumors. Recent Results in Cancer Research, 157, 55-81.

Pre 2000

Sherman, L., Sleeman, J.P., Hennigan, R., Herrlich, P. and Ratner, N. (1999). Overexpression of activated neu/erbB2 initiates immortalisation and malignant transformation of immature schwann cells in vitro. Oncogene, 18,6692-6699.

Sleeman, J.P., Kim, U., LePendu, J., Coquerelle, T., Ponta, P. and Herrlich, P. (1999). Inhibition of MT-450 rat mammary tumour growth by antibodies recognising subtypes of blood group antigen B. Oncogene, 18, 4485-4494.

Fieber, C., Plug, R., Sleeman, J.P., Dall, P., Ponta, H. and Herrlich, P. (1999). Characterization of the murine gene encoding the intracellular hyaluronan receptor IHABP (RHAMM). Gene, 226, 41-50.

Katagiri, Y., Sleeman, J.P., Fujii, H., Herrlich, P., Tanaka, K., Ijima, K., Murakami, M., Saiki, I., Chambers, A. and Uede, T. (1999). Enhancement of cell binding to osteopontin through CD44-mediated signalling in RGD-independent and beta 1 Integrin-dependent manner. Cancer Res., 59, 219-226.

Hofmann, M., Assmann, V., Fieber, C., Sleeman, J.P., Moll, J., Ponta, H., Hart, I. R. and Herrlich, P. (1998). Problems with RHAMM: a new link between surface adhesion and oncogenesis. Cell, 95, 591-592.

Herrlich, P., Sleeman, J.P., Wainwright, D., König, H., Sherman, L., Hilberg, F. and Ponta, H. (1998). How tumor cells make use of CD44. Cell Adhesion and Communication, 6, 141-147.

Weiss, J. M., Renkl, A. C., Sleeman, J.P., Dittmar, H., Termeer, C., Taxis, S., Howells, N., Schöpf, E., Ponta, H., Herrlich P. and Simon, J. C. (1998). CD44 variant isoforms are essential for the function of epidermal Langerhans cells and dendritic cells. Cell Adhesion and Communication, 6, 157-160.

Moll., J., Khaldoianidi, S., Sleeman, J.P., Preuss, I., Ponta, H. and Herrlich, P. (1998). Two different roles for CD44 proteins in human myelopoiesis. J. Clin. Invest., 102, 1024-1034

Sleeman, J.P., Rahmsdorf, U., Stefan, A., Ponta, H. and Herrlich, P. (1998). CD44 exon v5 encodes a tyrosine which is sulfated. Eur. J. Biochem., 255, 74-80.

Gao, A., Lou, W., Sleeman, J.P. and Isaacs, J. (1998). Metastasis suppression by the standard CD44 isoform does not require binding of prostate cells to hyaluronate. Cancer Research, 58, 2350-2352.

Hofmann, M., Fieber, C., Assmann, V., Göttlicher, M., Sleeman, J.P., Plug, R., Howells, N., von Stein, O., Ponta, H. and Herrlich, P. (1998). Identification of IHABP, a 95kD intracellular hyaluronate binding protein. J. Cel.l Sci., 111, 1673-1684.

Amaravadi, L.S., Neff, A.W., Sleeman, J.P. and Smith, R.C. (1997). Autonomous neural axis formation by ectopic expression of the protooncogene c-ski. Dev. Biol., 192, 392-404.

Sleeman, J.P., Kondo, K., Moll, J., Ponta, H. and Herrlich, P. (1997). CD44 variant exons v6 and v7 together extend the repertoire of glycosaminoglycans bound by CD44. J. Biol. Chem., 272, 31837-31844.

Sleeman, J.P. (1997). Blood group antigen expression during metastasis and active cell death. FZK Nachrichten, 29 3/97, 241-243.

Weiss, J. M., Sleeman, J.P., Renkl, A. C., Termeer, C., Dittmar, H., Taxis, S., Howells, N., Hofmann, M., Schöpf, E., Ponta, H., Herrlich P. and Simon, J. C. (1997). An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function. J. Cell Biol., 137, 1137-1147.

Sleeman, J.P., Rudy, W., Hofmann, M., Moll, J., Ponta, P. and Herrlich, P. (1996). Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity. J. Cell Biol., 135, 1139-1150.

Sleeman, J.P., Arming, S., Moll, J., Hekele, A., Rudy, W., Hofmann, M., Kreil, G., Ponta, H. and Herrlich, P.(1996). Metastasis associated variants of CD44 bind to hyaluronic acid, but this binding is not required for their metastasis-conferring abilities. Cancer Research, 56, 3134-3141.

Sherman, L., Sleeman, J.P., Dall, P., Moll, J., Ponta, H. and Herrlich, P. (1996). The CD44 proteins in embryonic development and cancer. Current Topics in Microbiology and Immunology, 213, 249-269.

Wainwright, D., Sherman, S., Sleeman, J.P., Ponta, H. and Herrlich, P. (1996). A splice variant of CD44 expressed in the rat apical ectodermal ridge contributes to limb outgrowth. Ann. N. Y. Acad. Sci., 785, 345-349.

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