Publications and Theses

2024

Ludwig N, Cucinelli S, Hametner S, Muckenthaler MU, Schirmer L. Iron scavenging and myeloid cell polarization. Trends Immunol. 2024 Jul 24:S1471-4906(24)00155-8. doi: 10.1016/j.it.2024.06.006. Online ahead of print.PMID: 39054114 Free article. Review.

Hofman T, Ng SW, Garcés-Lázaro I, Heigwer F, Boutros M, Cerwenka A. IFNγ mediates the resistance of tumor cells to distinct NK cell subsets. J Immunother Cancer. 2024 Jul 1;12(7):e009410. doi: 10.1136/jitc-2024-009410.PMID: 38955423 

Jeong M, Cortopassi F, See JX, De La Torre C, Cerwenka A, Stojanovic A. Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation. Eur J Immunol. 2024 Jul;54(7):e2250342. doi: 10.1002/eji.202250342. Epub 2024 Apr 9.PMID: 38593338

Lisa-Marie Rieckmann, Michael Spohn, Lisa Ruff, David Agorku, Lisa Becker, Alina Borchers, Jenny Krause, Roisin O’Reilly, Jurek Hille, Janna-Lisa Velthaus-Rusik, Niklas Beumer, Armin Günther, Lena Willnow, Charles D. Imbusch, Peter Iglauer, Ronald Simon, Sören Franzenburg, Hauke Winter, Michael Thomas, Carsten Bokemeyer, Nicola Gagliani, Christian F. Krebs, Martin Sprick, Olaf Hardt, Sabine Riethdorf, Andreas Trumpp, Nikolas H. Stoecklein, Sven Peine, Philipp Rosenstiel, Klaus Pantel, Sonja Loges & Melanie Janning.
Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells.
Mol Cancer 23, 93 (2024). https://doi.org/10.1186/s12943-024-01984-2

C.L. Tan, K. Lindner, T. Boschert, Z. Meng, A. Rodriguez Ehrenfried, A. De Roia, G. Haltenhof, A. Faenza, F. Imperatore, L. Bunse, J.M. Lindner, R.P. Harbottle, M. Ratliff, R. Offringa, I. Poschke, M. Platten and E.W. Green:
Tumor-reactive T-cell receptors are rapidly identified from lymphocyte scRNA-seq data.
Nature Biotechnology 2024, DOI: 10.1038/s41587-024-02161-y

Kilian M, Friedrich MJ, Lu KH, Vonhören D, Jansky S, Michel J, Keib A, Stange S, Hackert N, Kehl N, Hahn M, Habel A, Jung S, Jähne K, Sahm F, Betge J, Cerwenka A, Westermann F, Dreger P, Raab MS, Meindl-Beinker NM, Ebert M, Bunse L, Müller-Tidow C, Schmitt M, Platten M.
The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance
Sci Immunol. 2024 May 3;9(95):eadj7970. doi: 10.1126/sciimmunol.adj7970. Epub 2024 May 3. PMID: 38701193.

Natalie K Horvat, Sara Chocarro, Oriana Marques, Tobias A Bauer, Ruiyue Qiu, Alberto Diaz-Jimenez, Barbara Helm, Yuanyuan Chen, Stefan Sawall, Richard Sparla, Lu Su, Ursula Klingmüller, Matthias Barz, Matthias W Hentze, Rocío Sotillo, Martina U Muckenthaler.
Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment.
ACS Nano. 2024 Apr 16. doi: 10.1021/acsnano.3c08335. Online ahead of print PMID: 38626916 doi: 10.1021/acsnano.3c08335.

Weidner P, Saar D, Söhn M, Schroeder T, Yu Y, Zöllner FG, Ponelies N, Zhou X, Zwicky A, Rohrbacher FN, Pattabiraman VR, Tanriver M, Bauer A, Ahmed H, Ametamey SM, Riffel P, Seger R, Bode JW, Wade RC, Ebert MPA, Kragelund BB, Burgermeister E.
Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Cancer Lett. 2024 Mar 8:216783. doi: 10.1016/j.canlet.2024.216783. Online ahead of print. PMID: 38462034.

Velásquez, S. Y., Baslar, G. E., Schulte, J., Fuderer, T., Lindner, H. A., & Coulibaly, A. (2024).
Downregulation of hypoxia inducible factor-1α in primary human natural killer cells using small interfering RNA delivery with ExPERT ATx by MaxCyte.
Current Protocols, 4, e987. doi: 10.1002/cpz1.987

Yu Y, Farooq MS, Eberhart Meessen S, Jiang Y, Kato D, Zhan T, Weiss C, Seger R, Kang W, Zhang X, Yu J, Ebert MPA, Burgermeister E.
Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ.
Cell Death Dis. 2024 Jan 4;15(1):7. doi: 10.1038/s41419-023-06371-1.

2023

Kilian M*, Sheinin R*, Tan CL, Krämer C, Friedrich M, Kaminitz A, Sanghvi K, Lindner K, Chih YC, Cichon F, Richter B, Jung S, Jähne K, Ratliff M, Prins R, Etminan N, von Deimling A, Wick W, Madi A*, Bunse L*, Platten M*. MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors.
Cancer Cell. 2023. 41(2):235-251.e9. doi: 10.1016/j.ccell.2022.12.007. Epub 2023 Jan 12. *equal contribution.

Krämer C*, Kilian M*, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, Koopmann P, Sanghvi K, De Roia A, Jung S, Jähne K, Day B, Shultz LD, Ratliff M, Harbottle R, Green EW, Will R, Wick W, Platten M, Bunse L. NLGN4X TCR transgenic T cells to treat gliomas. Neuro Oncol. 2024 Sep 16:noad172. doi: 10.1093/neuonc/noad172. Epub 2023 Sep 16. 

Zhao B, Kilian M, Bunse T, Platten M, Bunse L. Tumor-reactive T helper cells in the context of vaccination against glioma. Cancer Cell. 2023. 41(11):1829-1834. doi: 10.1016/j.ccell.2023.09.013. Epub 2023 Oct 19. Commentary

Papaioannou S, See JX, Jeong M, De La Torre C, Ast V, Reiners-Koch PS, Sati A, Mogler C, Platten M, Cerwenka A, Stojanovic A: Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury. Cell Rep. 2023 Aug 29;42(8):112836. doi: 10.1016/j.celrep.2023.112836. Epub 2023 Jul 19.PMID: 37471222

Burgermeister E.
Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy.
Int J Mol Sci. 2023 Sep 4;24(17):13661. doi: 10.3390/ijms241713661

Burgermeister E.
Mitogen-Activated Protein Kinase and Exploratory Nuclear Receptor Crosstalk in Cancer Immunotherapy.
Int J Mol Sci. 2023 Sep 26;24(19):14546. doi: 10.3390/ijms241914546.

2022

Lu K, Michel J, Kilian M, Aslan K, Qi H, Kehl N, Jung S, Sanghvi K, Lindner K, Zhang XW, Green EW, Poschke I, Ratliff M, Bunse T, Sahm F, von Deimling A, Wick W, Platten M, Bunse L*. T cell receptor dynamic and transcriptional determinants of T cell expansion in glioma-infiltrating T cells. Neuro-Oncol Adv. 2022. 4(1):vdac140 doi:10.1093/noajnl/vdac140 eCollection 2022 Jan-Dec.

Thomann AK, Wüstenberg T, Wirbel J, Knoedler LL, Thomann PA, Zeller G, Ebert MP, Lis S, Reindl W.
Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
BMC Med. 2022 Oct 17;20(1):366. doi: 10.1186/s12916-022-02550-7.

Hinsenkamp I, Köhler JP, Flächsenhaar C, Hitkova I, Meessen SE, Gaiser T, Wieland T, Weiss C, Röcken C, Mowat M, Quante M, Taxauer K, Mejias-Luque R, Gerhard M, Vogelmann R, Meindl-Beinker N, Ebert M, Burgermeister E.
Functional antagonism between CagA and DLC1 in gastric cancer.
Cell Death Discov. 2022 Aug 13;8(1):358. doi: 10.1038/s41420-022-01134-x.

Ebert MP, Meindl-Beinker NM, Gutting T, Maenz M, Betge J, Schulte N, Zhan T, Weidner P, Burgermeister E, Hofheinz R, Vogel A, Angermeier S, Bolling C, de Wit M, Jakobs R, Karthaus M, Stocker G, Thuss-Patience P, Leidig T, Gaiser T, Kather JN, Haertel N.
Second-line therapy with nivolumab plus ipilimumab for older patients with oesophageal squamous cell cancer (RAMONA): a multicentre, open-label phase 2 trial.
Lancet Healthy Longev. 2022 Jun;3(6):e417-e427. doi: 10.1016/S2666-7568(22)00116-7.

Betge J, Rindtorff N, Sauer J, Rauscher B, Dingert C, Gaitantzi H, Herweck F, Srour-Mhanna K, Miersch T, Valentini E, Boonekamp KE, Hauber V, Gutting T, Frank L, Belle S, Gaiser T, Buchholz I, Jesenofsky R, Härtel N, Zhan T, Fischer B, Breitkopf-Heinlein K, Burgermeister E, Ebert MP, Boutros M.
The drug-induced phenotypic landscape of colorectal cancer organoids.
Nat Commun. 2022 Jun 6;13(1):3135. doi: 10.1038/s41467-022-30722-9.

Lerma-Martin C, Badia-i-Mompel P, Ramirez Flores RO, Sekol P, Hofmann A, Thäwel T, Riedl CJ, Wünnemann F, Ibarra-Arellano MA, Trobisch T, Eisele P, Schapiro D, Haeussler M, Hametner S, Saez-Rodriguez J, Schirmer L.
Spatial cell type mapping of multiple sclerosis lesions.
bioRxiv preprint. 2022 Nov 3. doi: 10.1101/2022.11.03.514906