Publications

2022

Agelopoulos K, Wiegmann H, Schmelz M, Stander S. [Neurobiology of pruritus: new concepts]. Dermatologie (Heidelb). 2022; 73:593-9.

Behrendt M. TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms. Biol. Chem. 2022;

Behrendt M, Solinski HJ, Schmelz M, Carr R. Bradykinin-Induced Sensitization of Transient Receptor Potential Channel Melastatin 3 Calcium Responses in Mouse Nociceptive Neurons. Front Cell Neurosci. 2022; 16:843225.

Dehghan Nayyeri M, Missler M, Ritterbach R, Sundermann B, Wulms N, Suer A, Dugas M, Pereira MP, Stander S, Schmelz M, Pfleiderer B. Altered resting-state functional connectivity of default mode network in brachioradial pruritus. J. Eur. Acad. Dermatol. Venereol. 2022; 36:2214-23.

Landmann G, Stockinger L, Gerber B, Benrath J, Schmelz M, Rukwied R. Local hyperexcitability of C-nociceptors may predict responsiveness to topical lidocaine in neuropathic pain. PLoS ONE. 2022; 17:e0271327.

Liu S, Bonalume V, Gao Q, Chen JT, Rohr K, Hu J, Carr R. Pre-Synaptic GABA(A) in NaV1.8(+) Primary Afferents Is Required for the Development of Punctate but Not Dynamic Mechanical Allodynia following CFA Inflammation. Cells. 2022; 11

Lunden LK, Kleggetveit IP, Schmelz M, Jorum E. Cold allodynia is correlated to paroxysmal and evoked mechanical pain in complex regional pain syndrome (CRPS). Scand J Pain. 2022; 22:533-42.

Pereira MP, Schmelz M, Stander S. Mechanisms and therapeutic targets for neuropathic itch. Curr. Opin. Neurobiol. 2022; 75:102573.

Schmelz M. Lessons learned - Moving on from QST sensory profiles. Scand J Pain. 2022; 22:670-2.

Handwerker H, Jørum E, Schady W, LaMotte R, Schmelz M. Erik Torebjörk, MD
PhD, Professor of Clinical Pain Research 1939-2021 Forerunner and lead researcher of human nociceptor research. Eur J Pain. 2022 Feb;26(2):275-279.

2021

Ständer S, Sun YG, Schmelz M. Editorial: Pruritus Medicine. Front Med (Lausanne). 2021 Sep 28;8:763667.

Schmelz M. How Do Neurons Signal Itch? Front Med (Lausanne). 2021 Mar 15;8:643006.

Schmelz M. Reply to Vollert et al. Pain. 2021 Apr 1;162(4):1274-1275.

Vollert J, Schmelz M. Reply to Bordeleau et al. Pain. 2021 Nov 1;162(11):2780.

Solinski, H.J., R. Rukwied, and M. Schmelz. 2021. Microinjection of pruritogens in NGF-sensitized human skin. Sci Rep. 2021 Nov 2; 11:21490.

Papotto N, Reithofer S, Baumert K, Carr R, Möhrlen F, Frings S. Olfactory stimulation Inhibits Nociceptive Signal Processing at the Input Stage of the Central Trigeminal System. Neuroscience. 2021 Dec 15;479:35-47

Schmelz M. What can we learn from the failure of quantitative sensory testing? Pain. 2021 Mar 1;162(3):663-664.

Meijs S, Schmelz M, Meilin S, Jensen W. A systematic review of porcine models in translational pain research. Lab Anim (NY). 2021 Nov;50(11):313-326.

Bali KK, Gandla J, Rangel DR, Castaldi L, Mouritzen P, Agarwal N, Schmelz M, Heppenstall P, Kuner R. A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy. Pain. 2021 May 1;162(5):1334-1351.

Bonalume V, Caffino L, Castelnovo LF, Faroni A, Liu S, Hu J, Milanese M, Bonanno G, Sohns K, Hoffmann T, De Col R, Schmelz M, Fumagalli F, Magnaghi V, Carr R. Axonal GABA_A stabilizes excitability in unmyelinated sensory
axons secondary to NKCC1 activity. J Physiol. 2021 Sep;599(17):4065-4084.

Klein A, Solinski HJ, Malewicz NM, Ieong HF, Sypek EI, Shimada SG, Hartke TV, Wooten M, Wu G, Dong X, Hoon MA, LaMotte RH, Ringkamp M. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. Elife. 2021 Apr 23;10:e64506.

Werland F, Hirth M, Rukwied R, Ringkamp M, Turnquist B, Jorum E, Namer B, Schmelz M, Obreja O. Maximum axonal following frequency separates classes of cutaneous unmyelinated nociceptors in the pig. J Physiol. 2021 Mar;599(5):1595-1610.

Schnakenberg M, Thomas C, Schmelz M, Rukwied R. Nerve growth factor sensitizes nociceptors to C-fibre selective supra-threshold electrical stimuli in human skin. Eur J Pain. 2021 Feb;25(2):385-397.

Werland F, de Col R, Hirth M, Turnquist B, Schmelz M, Obreja O. Mechanical sensitization, increased axonal excitability, and spontaneous activity in C-nociceptors after ultraviolet B irradiation in pig skin. Pain. 2021 Jul 1;162(7):2002-2013.

Bonalume V, Caffino L, Castelnovo LF, Faroni A, Liu S, Hu J, Milanese M, Bonanno G, Sohns K, Hoffmann T, De Col R, Schmelz M, Fumagalli F, Magnaghi V, Carr R. Axonal GABA_A stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity. J Physiol. 2021 Sep;599(17):4065-4084.

Fryk E, Olausson J, Mossberg K, Strindberg L, Schmelz M, Brogren H, Gan LM, Piazza S, Provenzani A, Becattini B, Lind L, Solinas G, Jansson PA. Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study. EBioMedicine. 2021 Mar;65:103264.

Solinski HJ, Rukwied R. Electrically Evoked Itch in Human Subjects. Front Med (Lausanne). 2021 Jan 20;7:627617.

2020

Schmelz M, Ständer S. Pruritusmedizin – Austausch der Disziplinen [Pruritus medicine-interdisciplinary exchange]. Hautarzt. 2020 Jul;71(7):485-486. German.

Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29090-29100.

Ständer S, Schmelz M. Neuropathischer Pruritus [Neuropathic pruritus]. Schmerz. 2020 Dec;34(6):525-535. German. doi: 10.1007/s00482-020-00502-9. Epub 2020 Oct 6.

Agarwal N, Taberner FJ, Rangel Rojas D, Moroni M, Omberbasic D, Njoo C, Andrieux A, Gupta P, Bali KK, Herpel E, Faghihi F, Fleming T, Dejean A, Lechner SG, Nawroth PP, Lewin GR, Kuner R. SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes. Neuron. 2020 Sep 23;107(6):1141-1159.

Schmelz M. Pruritus – ein weiter Weg von der Neurophysiologie zur Klinik [Pruritus-a long journey from neurophysiology to the clinic]. Hautarzt. 2020 Jul;71(7):487-492. German.

Jonas R, Prato V, Lechner SG, Groen G, Obreja O, Werland F, Rukwied R, Klusch A, Petersen M, Carr RW, Schmelz M. TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors. Front Cell Neurosci. 2020 Feb 7;14:13.

Liu H, Andoh J, Lyu Y, Milde C, Desch S, Zidda F, Schmelz M, Curio G, Flor H. Peripheral input and phantom limb pain: A somatosensory event-related potential study. Eur J Pain. 2020 Aug;24(7):1314-1329.

Rukwied R, Schnakenberg M, Solinkski HJ, Schmelz M, Weisshaar E. Transcutaneous Slowly Depolarizing Currents Elicit Pruritus in Patients with Atopic Dermatitis. Acta Derm Venereol. 2020 Oct 28;100(17):adv00302.

Jonas R, Namer B, Schnakenberg M, Soares S, Pakalniskis J, Carr R, Schmelz M, Rukwied R. Sympathetic efferent neurons are less sensitive than nociceptors to 4 Hz sinusoidal stimulation. Eur J Pain. 2020 Jan;24(1):122-133.

Rukwied R, Thomas C, Obreja O, Werland F, Kleggetveit IP, Jorum E, Carr RW, Namer B, Schmelz M. Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin. Pain. 2020 Sep1;161(9):2119-2128.

Bonalume V, Caffino L, Castelnovo LF, Faroni A, Giavarini F, Liu S, Caruso D, Schmelz M, Fumagalli F, Carr RW, Magnaghi V. Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons. Cells. 2020 Aug 11;9(8):1874.

Kokotis P, Manios E, Schmelz M, Fotiou D, Dialoupi I, Gavriatopoulou M, Roussou M, Lykka A, Dimopoulos MA, Kastritis E. Involvement of small nerve fibres and autonomic nervous system in AL amyloidosis: comprehensive characteristics and clinical implications. Amyloid. 2020 Jun;27(2):103-110.

Davids M, Guérin B, Klein V, Schmelz M, Schad LR, Wald LL. Optimizing selective stimulation of peripheral nerves with arrays of coils or surface electrodes using a linear peripheral nerve stimulation metric. J Neural Eng. 2020 Jan 14;17(1):016029.

2019

Yosipovitch G, Misery L, Proksch E, Metz M, Ständer S, Schmelz M. Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions. Acta Derm Venereol. 2019 Dec 1;99(13):1201-1209.

Subhash S, Kalmbach N, Wegner F, Petri S, Glomb T, Dittrich-Breiholz O, Huang C, Bali KK, Kunz WS, Samii A, Bertalanffy H, Kanduri C, Kar S. Transcriptome-wide Profiling of Cerebral Cavernous Malformations Patients Reveal Important Long noncoding RNA molecular signatures. Sci Rep. 2019 Dec 3;9(1):18203.

Schwarz ML, Reisig G, Schütte A, Becker K, Serba S, Forsch E, Thier S, Fickert S, Lenz T, Weiß C, Hetjens S, Bludau F, Bothe F, Richter W, Schneider-Wald B. Report on a large animal study with Göttingen Minipigs where regenerates
and controls for articular cartilage were created in a large number. Focus on the conditions of the operated stifle joints and suggestions for standardized procedures. PLoS One. 2019 Dec 26;14(12):e0224996.

Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain. 2019
Oct;160(10):2210-2220.

Steinhoff M, Oaklander AL, Szabó IL, Ständer S, Schmelz M. Neuropathic itch. Pain. 2019 May;160 Suppl 1:S11-S16.

Schmelz M. Itch Processing in the Skin. Front Med (Lausanne). 2019 Jul 19;6:167. doi: 10.3389/fmed.2019.00167.

Dusch M, Schmelz M. Erythromelalgie: rote Haut und Schmerz [Erythromelalgia: skin redness and pain]. Schmerz. 2019 Oct;33(5):475-490. German.

Maurer M, Papotto N, Sertel-Nakajima J, Schueler M, De Col R, Möhrlen F, Messlinger K, Frings S, Carr RW. Photoactivation of olfactory sensory neurons does not affect action potential conduction in individual trigeminal sensory axons innervating the rodent nasal cavity. PLoS One. 2019 Aug 14;14(8).

Baumann KY, Church MK, Clough GF, Quist SR, Schmelz M, Skov PS, Anderson CD, Tannert LK, Giménez-Arnau AM, Frischbutter S, Scheffel J, Maurer M. Skin microdialysis: methods, applications and future opportunities-an EAACI position paper. Clin Transl Allergy. 2019 Apr 10;9:24.

Kostidou E, Schmelz M, Hasemaki N, Kokotis P. Objective Methods for Breast Sensibility Testing. Plast Reconstr Surg. 2019 Feb;143(2):398-404.

Schmelz M, Häuser W, Hoch E, Petzke F, Sommer C. Cannabisbasierte Arzneimittel : Expertenkonsens gegen systematische Übersichtsarbeiten? [Cannabis-based drugs : Don't pit clinical experience and systematic reviews against each other]. Schmerz. 2019 Apr;33(2):97-99. German.

Tsianakas A, Nippe N, Hamper CM, Cordes AF, Zeidler C, Schmelz M, Ständer S. Exploratory Study of Intracutaneous Histamine Stimulation in Patient Populations with Chronic Pruritus. Acta Derm Venereol. 2019 Mar 1;99(3):291-297.

Pereira MP, Agelopoulos K, Köllner J, Neufang G, Schmelz M, Ständer S. Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization? Acta Derm Venereol. 2019 Oct 1;99(11):1009-1015.

Solinski HJ, Dranchak P, Oliphant E, Gu X, Earnest TW, Braisted J, Inglese J, Hoon MA. Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Sci Transl Med. 2019 Jul 10;11(500):eaav5464.

Meents JE, Bressan E, Sontag S, Foerster A, Hautvast P, Rösseler C, Hampl M, Schüler H, Goetzke R, Le TKC, Kleggetveit IP, Le Cann K, Kerth C, Rush AM, Rogers M, Kohl Z, Schmelz M, Wagner W, Jørum E, Namer B, Winner B, Zenke M,
Lampert A. The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients. Pain. 2019 Jun;160(6):1327-1341.

Hidding J, Agelopoulos K, Pereira MP, Conrad H, Hatt H, Lotts T, Osada N, Pogatzki-Zahn E, Schmelz M, Ständer S. Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study. Acta Derm Venereol. 2019 Jun 1;99(7):668-674.

Behrendt M. Transient receptor potential channels in the context of nociception and pain - recent insights into TRPM3 properties and function. Biol Chem. 2019 Jun 26;400(7):917-926.

Solinski HJ, Kriegbaum MC, Tseng PY, Earnest TW, Gu X, Barik A, Chesler AT, Hoon MA. Nppb Neurons Are Sensors of Mast Cell-Induced Itch. Cell Rep. 2019 Mar 26;26(13):3561-3573.e4.

Carr R, Frings S. Neuropeptides in sensory signal processing. Cell Tissue Res. 2019 Jan;375(1):217-225.

2018

Steinhoff M, Schmelz M, Szabó IL, Oaklander AL. Clinical presentation, management, and pathophysiology of neuropathic itch. Lancet Neurol. 2018 Aug;17(8):709-720.

Meyer NH, Gibbs B, Schmelz M, Homey B, Raap U. Neurophysiologie des atopischen Pruritus [Neurophysiology of atopic pruritus]. Hautarzt. 2018 Mar;69(3):204-209. German.

Pereira MP, Agelopoulos K, Kremer AE, Schmelz M. Aktuelles zur Neurobiologie von Pruritus [New findings regarding the neurobiology of pruritus]. Hautarzt. 2018 Aug;69(8):620-625. German.

Schmelz M. Quantitative sensory test correlates with neuropathy, not with pain. Pain. 2018 Mar;159(3):409-410.

Obreja O, Rukwied R, Nagler L, Schmidt M, Schmelz M, Namer B. Nerve growth factor locally sensitizes nociceptors in human skin. Pain. 2018 Mar;159(3):416-426.

Jonas R, Namer B, Stockinger L, Chisholm K, Schnakenberg M, Landmann G, Kucharczyk M, Konrad C, Schmidt R, Carr R, McMahon S, Schmelz M, Rukwied R. Tuning in C-nociceptors to reveal mechanisms in chronic neuropathic pain. Ann
Neurol. 2018 May;83(5):945-957.

Sauerstein K, Liebelt J, Namer B, Schmidt R, Rukwied R, Schmelz M. Low- Frequency Stimulation of Silent Nociceptors Induces Secondary Mechanical Hyperalgesia in Human Skin. Neuroscience. 2018 Sep 1;387:4-12. doi:10.1016/j.neuroscience.2018.03.006. Epub 2018 Mar 15.

Klusch A, Gorzelanny C, Reeh PW, Schmelz M, Petersen M, Sauer SK. Local NGF and GDNF levels modulate morphology and function of porcine DRG neurites, In Vitro. PLoS One. 2018 Sep 27;13(9):e0203215.

Huang J, Polgár E, Solinski HJ, Mishra SK, Tseng PY, Iwagaki N, Boyle KA, Dickie AC, Kriegbaum MC, Wildner H, Zeilhofer HU, Watanabe M, Riddell JS, Todd AJ, Hoon MA. Author Correction: Circuit dissection of the role of somatostatin
in itch and pain. Nat Neurosci. 2018 Jun;21(6):894.

Agarwal N, Helmstädter J, Rojas DR, Bali KK, Gangadharan V, Kuner R. Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice. Mol Pain.  2018 Jan-Dec;14:1744806918817975.

2017

Zeng Y, Hahn S, Stokes J, Hoffman EA, Schmelz M, Proytcheva M, Chernoff J, and Katsanis E. Pak2 regulates myeloid-derived suppressor cell development in mice. Blood Adv. 2017;1(22):1923-33.

Vogel C, Rukwied R, Stockinger L, Schley M, Schmelz M, Schleinzer W, and Konrad C. Functional Characterization of At-Level Hypersensitivity in Patients With Spinal Cord Injury. The journal of pain : official journal of the American Pain Society. 2017;18(1):66-78.

Stumpf A, Pfleiderer B, Schneider G, Heuft G, Schmelz M, Phan NQ, Stander S, and Burgmer M. Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation. Acta dermato-venereologica. 2017;97(9):1074-80.

Schmelz M. [Q14 pain medicine in medical studies: glass half full or half empty?]. Schmerz. 2017;31(4):343-4.

Schmelz M. [Chronic pain: interaction between somatic and psychological factors (F45.41)]. Schmerz. 2017;31(6):551-2.

Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stab F, Terstegen L, Kolbe L, et al. Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells. Experimental dermatology. 2017;26(1):44-50.

Nawroth PP, Bendszus M, Pham M, Jende J, Heiland S, Ries S, Schumann C, Schmelz M, Schuh-Hofer S, Treede RD, et al. The quest for more research on painful diabetic neuropathy. Neuroscience. 2017.

Namer B, Orstavik K, Schmidt R, Mair N, Kleggetveit IP, Zeidler M, Martha T, Jorum E, Schmelz M, Kalpachidou T, et al. Changes in Ionic Conductance Signature of Nociceptive Neurons Underlying Fabry Disease Phenotype. Front Neurol. 2017;8(335.

Kokotis P, Schmelz M, Papagianni AE, Zambelis T, and Karandreas N. Decreased Axon Flare Reaction to Electrical Stimulation in Patients With Chronic Demyelinating Inflammatory Polyneuropathy. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2017;34(2):101-6.

Klein AH, Vyshnevska A, Hartke TV, De Col R, Mankowski JL, Turnquist B, Bosmans F, Reeh PW, Schmelz M, Carr RW, et al. Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves. J Neurosci. 2017;37(20):5204-14.

Helas T, Sagafos D, Kleggetveit IP, Quiding H, Jonsson B, Segerdahl M, Zhang Z, Salter H, Schmelz M, and Jorum E. Pain thresholds, supra-threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in NaV 1.7. European journal of pain (London, England). 2017;21(8):1316-25.

Gonzalez-Rodriguez S, Quadir MA, Gupta S, Walker KA, Zhang X, Spahn V, Labuz D, Rodriguez-Gaztelumendi A, Schmelz M, Joseph J, et al. Polyglycerol-opioid conjugate produces analgesia devoid of side effects. Elife. 2017;6

Carstens E, Schmelz M, Hunter HJA, Lerner EA, Misery L, Steinhoff M, Yosipovitch G, and Stander S. FRT - FONDATION RENE TOURAINE: An International Foundation For Dermatology. Experimental dermatology. 2017;26(10):972-85.

2016

Steinhoff M, Schmelz M, and Schauber J. Facial Erythema of Rosacea - Aetiology, Different Pathophysiologies and Treatment Options. Acta dermato-venereologica. 2016;96(5):579-86.

Sagafos D, Kleggetveit IP, Helas T, Schmidt R, Minde J, Namer B, Schmelz M, and Jorum E. Single-Fiber Recordings of Nociceptive Fibers in Patients With HSAN Type V With Congenital Insensitivity to Pain. The Clinical journal of pain. 2016;32(7):636-42.

Raap U, Papakonstantinou E, Metz M, Lippert U, and Schmelz M. [Update on the cutaneous neurobiology of pruritus]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 2016;67(8):595-600.

Murdolo G, Piroddi M, Tortoioli C, Bartolini D, Schmelz M, Luchetti F, Canonico B, Papa S, Zerbinati C, Iuliano L, et al. Free Radical-derived Oxysterols: Novel Adipokines Modulating Adipogenic Differentiation of Adipose Precursor Cells. The Journal of clinical endocrinology and metabolism. 2016;101(12):4974-83.

Landmann G, Stockinger L, Lustenberger C, Schmelz M, and Rukwied R. Effects of Current Density on Nociceptor Activation Upon Electrical Stimulation in Humans. Pain practice : the official journal of World Institute of Pain. 2016;16(3):273-81.

Landmann G, Lustenberger C, Schleinzer W, Schmelz M, Stockinger L, and Rukwied R. Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans. European journal of pain (London, England). 2016;20(9):1443-53.

Kokotis P, Schmelz M, Papagianni AE, Zambelis T, and Karandreas N. Impaired function of C-nociceptors in chronic inflammatory demyelinating polyradiculopathy indicated by electrically induced axon flare reflex. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2016.

Kokotis P, Schmelz M, Kostouros E, Karandreas N, and Dimopoulos MA. Oxaliplatin-Induced Neuropathy: A Long-Term Clinical and Neurophysiologic Follow-Up Study. Clinical colorectal cancer. 2016;15(3):e133-40.

Kleggetveit IP, Schmidt R, Namer B, Salter H, Helas T, Schmelz M, and Jorum E. Pathological nociceptors in two patients with erythromelalgia-like symptoms and rare genetic Nav 1.9 variants. Brain and behavior. 2016;6(10):e00528.

Kist AM, Sagafos D, Rush AM, Neacsu C, Eberhardt E, Schmidt R, Lunden LK, Orstavik K, Kaluza L, Meents J, et al. SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing. PloS one. 2016;11(9):e0161789.

Fryk E, Sundelin JP, Strindberg L, Pereira MJ, Federici M, Marx N, Nystrom FH, Schmelz M, Svensson PA, Eriksson JW, et al. Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin-1 in type 2 diabetes patients. Metabolism: clinical and experimental. 2016;65(7):998-1006.

Dusch M, van der Ham J, Weinkauf B, Benrath J, Rukwied R, Ringkamp M, Schmelz M, Treede RD, and Baumgartner U. Laser-evoked potentials mediated by mechano-insensitive nociceptors in human skin. European journal of pain (London, England). 2016;20(5):845-54.

2015

Zeilhofer HU, and Schmelz M. Local anesthetics take a central action in analgesia. Pain. 2015;156(9):1579-80.

Weinkauf B, Obreja O, Schmelz M, and Rukwied R. Differential time course of NGF-induced hyperalgesia to heat versus mechanical and electrical stimulation in human skin. European journal of pain (London, England). 2015;19(6):789-96.

Weinkauf B, Dusch M, van der Ham J, Benrath J, Ringkamp M, Schmelz M, and Rukwied R. Mechano-sensitive nociceptors are required to detect heat pain thresholds and cowhage itch in human skin. European journal of pain (London, England). 2015.

Weinkauf B, Deising S, Obreja O, Hoheisel U, Mense S, Schmelz M, and Rukwied R. Comparison of nerve growth factor-induced sensitization pattern in lumbar and tibial muscle and fascia. Muscle Nerve. 2015;52(2):265-72.

Tigerholm J, Petersson ME, Obreja O, Eberhardt E, Namer B, Weidner C, Lampert A, Carr RW, Schmelz M, and Fransen E. C-fiber recovery cycle supernormality depends on ion concentration and ion channel permeability. Biophys J. 2015;108(5):1057-71.

Schmelz M. Itch and pain differences and commonalities. Handb Exp Pharmacol. 2015;227(285-301.
Schmelz M. Neurophysiology and itch pathways. Handb Exp Pharmacol. 2015;226(39-55.

Schmelz M. Nociceptors in the skin: fire-raisers to be kept at bay? Experimental dermatology. 2015.
Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, and Neufang G. UV radiation induces CXCL5 expression in human skin. Experimental dermatology. 2015;24(4):309-12.

Namer B, Schick M, Kleggetveit IP, Orstavik K, Schmidt R, Jorum E, Torebjork E, Handwerker H, and Schmelz M. Differential sensitization of silent nociceptors to low pH stimulation by prostaglandin E2 in human volunteers. European journal of pain (London, England). 2015;19(2):159-66.

Namer B, Orstavik K, Schmidt R, Kleggetveit IP, Weidner C, Mork C, Kvernebo MS, Kvernebo K, Salter H, Carr TH, et al. Specific changes in conduction velocity recovery cycles of single nociceptors in a patient with erythromelalgia with the I848T gain-of-function mutation of Nav1.7. Pain. 2015;156(9):1637-46.

Jonas R, Klusch A, Schmelz M, Petersen M, and Carr RW. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. PloS one. 2015;10(9):e0139107.